In this investigation, a novel temperature-pH responsive copolymer was prepared by the radical copolymerization between 2-hydroxypropyl acrylate (HPA) and aminoethyl methacrylate hydrochloric salt (AMHS). The molecular structure of the corresponding copolymer has been confirmed by 1H NMR and FTIR measurements. The results indicated that the lower critical solution temperature (LCST) of the resu...

Smart-controlled surface wettability from superhydrophilicity to superhydrophobicity has been extensively explored, and stimulus-responsive strategies have widely accepted as a useful method realize reversibility. However, achieving smart precise wetting control remains challenging because most previous studies focused on stimulating single chemistry or microstructures. Herein, dual-stimulus-re...

Herein, we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermoresponsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior and have an exceptionally high specific absorption rate (SAR), but their functionalization is extremely cha...

Chemically responsive polymers are macromolecules that respond to local variations of the chemical composition solution by changing their conformation, with notable examples including polyelectrolytes, proteins, and DNA. The polymer conformation changes can occur in response pH, ionic strength, or concentration a generic solute interacts polymer. These stimuli lead drastic flexibility even trig...

Original core/corona nanoparticles composed of a maghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions an...

Water-soluble copolymers of N-acryloyl-N′-ethylpiperazine (AcrNEP) with methyl methacrylate (MMA) were synthesized to high conversion by free-radical solution polymerization. The composition of the copolymers was determined using Fourier Transform Infra-red Spectroscopy (FTIR). Copolymers containing AcrNEP content above 44 mol% were readily soluble in water and exhibited the critical solution t...

Novel glucose-sensitive systems for the release of insulin from poly(diethylaminoethyl methacrylate) (PDEAEM) micro-particles and nanoparticles decorated with glucose oxidase and catalase enzymes have been developed. The effect of polymer composition and loading conditions on the insulin loading efficiency and release was studied. The optimal conditions for loading insulin into PDEAEM micropart...

In the present work, a grafted polymer of polyacrylamide with gum arabica was synthesized as Gum acacia-g-polyacrylamide using microwave-assisted synthesis ceric ammonium nitrate reaction initiator. The utilized in combination sodium alginate to prepare interpenetrating network hydrogel beads effectively deliver gabapentin gastrointestinal tract. formulated microbeads showed pH-responsive relea...

the aim of the research work was to chemically modify guar gum(gg) as a ph sensitive co-polymer and formulating intestinal targeting eso nanoparticles (nps) using the synthesized co-polymer. poly acrylamide-grafted-guar gum (paam-g-gg) co-polymer was synthesized by free radical polymerization. chemical modification of paam-g-gg by alkaline hydrolysis results in formation of a ph-sensitive co-po...