Hydrogels have become a promising research focus because of their potential for biomedical application. Here we explore the long-range, electrostatic interactions by following the effect of trans-acting (pH) and cis-acting factors (peptide mutation) on the formation of Au-phage hydrogels. These bioinorganic hydrogels can be generated from the bottom-up assembly of Au nanoparticles (Au NP) with ...

In recent years, several fluorenylmethoxycarbonyl (Fmoc)-functionalized amino acids and peptides have been used to construct hydrogels, which find a wide range of applications. Although several hydrogels have been prepared from mono Fmoc-functionalized amino acids, herein, we demonstrate the importance of an additional Fmoc-moiety in the hydrogelation of double Fmoc-functionalized L-lysine [Fmo...

Recent research has identified genipin as a promising natural crosslinking agent for biocompatible hydrogels as genipin is significantly less cytotoxic than current synthetic crosslinking agents, such as glutaraldehyde. Conveniently, fluorophores can be produced when genipin crosslinks. In this study, fluorescence intensity measurements of genipin crosslinked chitosan-poly(vinyl pyrrolidone) hy...

Hydrogels are hydrophilic, three-dimensional networks that are able to absorb large quantities of water or biological fluids, and thus have the potential to be used as prime candidates for biosensors, drug delivery vectors, and carriers or matrices for cells in tissue engineering. In this critical review article, advantages of the hydrogels that overcome the limitations from other types of biom...

Smart hydrogels, or stimuli-responsive hydrogels, are three-dimensional networks composed of crosslinked hydrophilic polymer chains that are able to dramatically change their volume and other properties in response to environmental stimuli such as temperature, pH and certain chemicals. Rapid and significant response to environmental stimuli and high elasticity are critical for the versatility o...

Intelligent, stimuli-responsive hydrogels have great utility in various fields spanning biomedical technology, separations, and catalysis. Their overall response to surrounding fluids may be further tailored to a specific application by incorporation of one or more intelligent responses within one material, known as multiresponsive hydrogels. This is a report on the facile synthesis and charact...

pH-responsive hydrogels are recognized as versatile sensors and actuators due to their unique time-dependent properties. Specifically, pH-sensitive hydrogel-based bilayers exhibit remarkable bending capabilities when exposed pH-triggered swelling. This study introduces a semi-analytical technique that combines non-linear solid mechanics with ionic species transport investigate the behavior of s...

Here we report the synthesis and characterization of pH-responsive, self-healing hydrogels based on boronate-catechol complexation.

Stimuli-sensitive hydrogel microspheres or microgels are polymeric particles that consist of cross-linked three-dimensional networks. They shrink or swell significantly by expelling or absorbing large amounts of water in response to external stimuli, such as changes in temperature, pH, electric or magnetic fields. The chemical composition of the microgel determines the stimulus that can trigger...

Oxanorbornadiene dicarboxylate (OND) reagents are potent Michael acceptors, the adducts of which undergo fragmentation by retro-Diels-Alder reaction at rates that vary with the substitution pattern on the OND moiety. Rapid conjugate addition between thiol-terminated tetravalent PEG and multivalent ONDs yielded self-supporting hydrogels within 1 min at physiological temperature and pH. Erosion o...