Carbon nanotubes (CNTs) are increasingly studied for innovative biotechnological applications particularly where they are combined with essential biological materials like lipids. Lipids have been used earlier for enhancing the dispersibility of CNTs in aqueous solutions. Here we report a novel application of CNTs for stabilization of internally self-assembled nanostructured lipid particles of ...

The oil of Adenanthera pavonina L. seeds was analysed by chromatographic and instrumental means. The oil was found to be rich in neutral lipids (86.2%), and low in polar lipids (13.8%). The neutral lipids consisted mainly of triacylglycerols (64.2%). Unsaturated fatty acids were found as high as 71%, while the percentage of saturated fatty acids was only 29%. GC and GC/MS analyses revealed lino...

Dry powder inhalers (DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this probl...

Gelatin has been used for many years in pharmaceutical formulation, cell culture and tissue engineering on account of its excellent biocompatibility, ease of processing and availability at low cost. Over the last decade gelatin has been extensively evaluated for numerous ocular applications serving as cell-sheet carriers, bio-adhesives and bio-artificial grafts. These different applications nat...

This review article describes the synthesis, properties and some applications of star-shaped polymers. The arms constituted of homoor co-polymers of different polymers are also reviewed. Methods of synthesis of various types of starshaped polymers, including “arm first” and “core first” procedures, is given as an introduction along with some details. Then, the synthesis of star polymers (includ...

Liposomes have been exploited for pharmaceutical purposes, including diagnostic imaging and drug and gene delivery. The versatility of liposomes as drug carriers has been demonstrated by a variety of clinically approved formulations. Since liposomes were first reported, research of liposomal formulations has progressed to produce improved delivery systems. One example of this progress is stealt...

Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and character...

Caseinophosphopeptides (CPP) were detected for the first time in ileostomy fluid, collected at 2 h intervals for 10 h post milk and CPP ingestion, from human volunteers with an ileostomy. The level of CPP present in ileostomy fluid obtained from milk-fed volunteers was markedly higher than that from volunteers fed with selected CPP preparations. The findings are based on HPLC analysis in combin...

The prototype taxane antineoplastic agent paclitaxel, was first isolated from the bark of the Western yew tree in 1971. It and its congener, the semisynthetic derivative docetaxel, display unique pharmacodynamics as mitotic spindle poisons, differing from the vinca alkaloids and colchicine derivatives in that they bind to a distinct site on β-tubulin and promote rather than inhibit microtubule ...

In the past decade, therapeutic potential of RNA interference (RNAi) and its application to human diseases were widely discussed in the related fields of biology, medical sciences, and pharmaceutical sciences. In course of these research and developing processes, efficient transduction of small interfering RNA (siRNA) into target cells is one of the most significant breakthroughs in revealing t...