Introduction . The low solubility of active pharmaceutical ingredients (APIs) in the physiological pH range intestinal tract can adversely affect their absorption and bioavailability. Various methods increasing APIs have been proposed recent decades. Among them there are preparation solid dispersions, micronization, solubilization other methods, including ones based on amorphization crystalline...

The preparation of stable amorphous pemetrexed disodium of pharmaceutical purity as well as the process optimization for the preparation of the hemipentahydrate form of pemetrexed disodium are described. Analytical methods for the polymorphic and chemical purity studies of pemetrexed disodium and pemetrexed diacid forms were developed. The physicochemical properties of the amorphous and hydrate...

There has been a significant and growing interest in chemical imaging of pharmaceutical tablets in recent years. Technology improvements and increased use has established chemical imaging as a means of providing information on certain critical quality parameters that is not readily addressable using other techniques. In addition to major pharmaceutical manufacturers, generic manufacturers and e...

Crystalline organic solids are ubiquitous as either final products or as intermediates in the specialty chemical, pharmaceutical, and home & personal care industries. Virtually all small molecular weight drugs are isolated as crystalline materials, and over 90% of all pharmaceutical products are formulated in particulate, generally crystalline form. Crystalline chemical intermediates, such as a...

Two bacterial strains were isolated from pharmaceutical effluents discharged soil. The samples were identified as Klebsiella pneumonia and Pseudomonas aeruginosa the biological degradation was carried on two bacterial isolates separately added to pharmaceutical effluent water. After proper interval were analysed the physic chemical parameters such as pH, Turbidity, Chemical oxygen demand (COD),...

The ‘Back-to-nature’ concept has currently been adopted intensively in various industries, especially the pharmaceutical industry. In past few decades, overuse of synthetic chemicals caused severe damage to environment and ecosystem. One class natural materials developed substitute artificial industries is polymers, including cellulose its derivatives. development nanocelluloses as nanocarriers...

Alzheimer’s Disease (AD) is a multifactorial neurological syndrome with the combination of aging, genetic, and environmental factors triggering the pathological decline. Interestingly, the importance of the Acetylcholinesterase (AChE) enzyme has increased due to its involvement in the β-amyloid peptide fibril formation during AD pathogenesis. In silico technique, QSAR has proven its usefulness ...

aDepartment of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology, University of Colorado Health Sciences Center, Denver, CO 80262 bDepartment of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, University of Colorado, Boulder, CO 80309 cDivision of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, ...