The pharmaceutical industry is moving through a period of great change. Not only are the global players consolidating, but companies are fundamentally changing the way they approach the market. “Big Pharma” has learned to focus on what it does best that is, the discovery and marketing of new products. All other endeavours are increasingly being out-sourced to a growing number of support laborat...

Convenient and simple procedures for the synthesis of functionalized Quinoxaline derivatives were developed via one-pot four-component reaction of o-aminoanilin, acetylenic ester, and malonyl dichloride in the presence of K2 CO3 as effective base catalyst. These compounds widely are used in various industries like paint, pharmaceutical and medicine. Quinoxaline derivatives are also part of anti...

Sargassum species are brown macroalgae found in shallow marine meadows. These are nutritious and rich source of several bioactive compounds. These isolated active compounds exhibit diverse biological activities like antioxidant, antiinflammatory, antipyretic, analgesic, antiviral, antidiabetic, hepatoprotective, anti-obesity, cholinesterase inhibitory activities etc. This makes the Sargassum sp...

Pharmaceutical development of therapeutic and imaging agents that improve tumor prognosis is an expensive R&D effort with many compounds in the preclinical testing pipeline (Olafsson et al., 2010). Introducing an efficient way to screen and reject unpromising compounds during the discovery research phase of development, such as in vivo preclinical imaging, could save some of the $800 million in...

Combinatorial chemistry is a new technique developed in pharmaceutical industry, which involves synthesis of compounds in mass instead of a single compound, which are screened as a whole mixture for particular biological activity. Because of the rapid synthesis of compounds, this method saves the time and cost associated with the drug discovery. This brief review article includes combinatorial ...

reports are written for those compounds that have undergone multilevel evaluations. A report analyzes and interprets the generated data, and also compares the candidate compound's pharmacodynamic and pharmacokinetic profile to that of current clinically effective drugs. Annually, approximately ten promising compounds are considered for further development by the ADD Program. If a compound appea...

In the past few decades, single enantiomers and stereoisomers have overtaken achiral molecules in the percentage of approved drugs in the market. Because isomers can have different biological/pharmacological/toxicological properties, authorities such as the European Pharmacopoeia and the FDA have asserted escalated emphasis on controlling isomer content in drug compounds and require that stereo...

Schiff bases are versatile ligands which are synthesized from the condensation of an amino compound with carbonyl compounds. These compounds and their metal complexes are very important as catalysts in various biological systems, polymers, dyes and medicinal and pharmaceutical fields. Their use in birth control, food packages and as an O2 detector is also outlined. This review summarizes the ap...