نتایج جستجو برای: pharmaceutical opioids
تعداد نتایج: 73685 فیلتر نتایج به سال:
introduction: optimum pain management immediately after surgeries can lower the possibility of pain syndrome and its following consequences. opioids are amongst the analgesics used for postoperative pain control; however, their application can bring about several adverse effects. in this study, all the published articles regarding efficacy of paracetamol in post-cardiac surgery pain managemen...
It has been more than two decades since neuraxial opioids first underwent rigorous clinical study for use in humans. The intraspinal route of administration is now commonly used to administer anesthetics and analgesics. Addition of opioids to intraspinal administered local anesthetic provides an effective and prolonged analgesia. However, the physiochemical properties of opioids may influence t...
Introduction: Substance abuse has been recognized as a national problem in which poisoning with pharmaceutical drugs, opioids and alcohols is common Iran. Due to the lack of comprehensive information system related abuse, despite systematic health services, achieve this goal, purpose research was develop registry for substance - Urmia University Medical Sciences.Material Methods: This practical...
Guidelines for the use of opioids in the treatment of chronic pain have recently been proposed by the American Academy of Addiction Psychiatry. Older guidelines proposed by American pain organizations had the effect of liberalizing opioid prescription. In recent years, dramatic increases in prescribed opioids have been followed by equally dramatic rises in morbidity and mortality from prescript...
objective : in this study, the effects of estradiol valerate and raloxifenea selective estrogen receptor modulator; (serm) on morphine induced sensitization were examined in mice memory, according to the step-down passive avoidance task. method: the mice received morphine or estradiol and raloxifene for three days alone or in combination with morphine. after a drug free period of 5 days, the su...
BACKGROUND The buprenorphine transdermal system (BTDS) is approved in the US for the management of chronic pain. Due to its high affinity for μ-opioid receptors with a slow dissociation profile, buprenorphine may potentially displace or prevent the binding of competing μ-opioid-receptor agonists, including immediate-release (IR) opioids, in a dose-dependent manner. Health care professionals may...
Introduction: Chronic drug use has been associated with a wide range of neuropsychological deficits. Therefore, this study aimed to evaluate the performance of the neuropsychological functions among three groups of opioids abusers, treated with methadone and non-user individuals. Methods: The causal-comparative research method was used in this study. The participants were selected through pu...
BACKGROUND Intrathecal opioid administration has been used widely in patients suffering from severe cancer pain that is not managed with conventional modalities. However, the potential serious neurological complications from the procedure and the side effects of intrathecal opioids have made many clinicians reluctant to employ continuous intrathecal analgesia as a first-line therapeutic option ...
INTRODUCTION While opioids are effective in carefully selected patients with chronic non-cancer pain (CNCP), they are associated with potential risks. Therefore, treatment recommendations for the safe and effective use of opioids in this patient population are needed. MATERIALS AND METHODS A multidisciplinary expert panel was convened by the Pain Association of Singapore to develop practical ...
It has now been demonstrated that the μ, δ1 , δ2 , and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR ago...
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