Various derivatives of thiazolidine-2,4-dione (C1–C5) were designed and synthesized by chemical reaction with 4-nitrobenzaldehyde using Knoevenagel conditions which results in the reduction nitro group to amine further modification target compounds. The structures all 2,4-thiazolidinedione have been elucidated 1H 13C NMR spectroscopy. These compounds characterized silico ADME (absorption, distr...

Chen, C. 2017. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 231. 58 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9877-1. Tuberculosis is an ancient infectious disease and a leading cause of death globally...

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...

Concomitant use of several drugs by ICU( Intensive Care Unit) patients is often unavoidable. In these patients, pharmacokinetic drug interactions are very likely. The current study was designed to evaluate these interactions in patients hospitalized in an ICU of a teaching hospital in Tehran, Iran. A questionnaire was designed and used to collect study data. The study was done in the ICU of a t...