BACKGROUND The basic premise of preadjusted bracket system is accurate bracket positioning. It is widely recognized that accurate bracket placement is of critical importance in the efficient application of biomechanics and in realizing the full potential of a preadjusted edgewise appliance. AIM The purpose of this study was to design a calibrating system to accurately detect a point on a plan...

Derived-band click-evoked auditory brainstem responses (ABRs) were obtained for normal-hearing (NH) and sensorineurally hearing-impaired (HI) listeners. The latencies extracted from these responses, as a function of derived-band center frequency and click level, served as objective estimates of cochlear response times. For the same listeners, auditory-filter bandwidths at 2 kHz were estimated u...

The aim of the present study was to investigate the effect of stimulus polarity on speech evoked auditory brainstem response (ABR). In order to accomplish it, speech evoked ABR was recorded with various stimulus polarities from 17 normally hearing adults. The result of the study shows differential effect of stimulus polarity on components of speech evoked ABR. Latency of peaks for onset, sustai...

In this paper, we describe an algorithm that automatically detects and labels peaks I-VII of the normal, suprathreshold auditory brainstem response (ABR). The algorithm proceeds in three stages, with the option of a fourth: (1) all candidate peaks and troughs in the ABR waveform are identified using zero crossings of the first derivative, (2) peaks I-VII are identified from these candidate peak...

The purpose of this study was to determine whether clicks presented in rarefaction or condensation modes produce more accurate diagnostic information. Subjects were 20 consecutive patients who were seen at the Mayo Clinic for unilateral acoustic neuromas. The nontumor ear served as a control to minimize intersubject variability in the latencies. A standard audiologic evaluation was followed by ...

Autophagy is quintessential for the maintenance of cellular homeostasis in all eukaryotic cells, explaining why both normal and malignant cells benefit from proficient autophagic responses. Moreover, autophagy intimately involved immunological control transformation, tumor progression response to therapy. However, net effect activation or inhibition on natural growth therapeutic tumors evolving...

The oral route is presently the preferred route of drug delivery. Poor oral bioavailability results in variable concentrations of drugs in the plasma and variable pharmacological responses, in addition to higher product costs. The unique canine physiology, anatomy and biochemistry makes designing canine dosage forms a challenging exercise. This article reviews the physicochemical, physiological...

The lectin chaperone calnexin (Cnx) is important for quality control of glycoproteins, and the chances of correct folding of a protein increase the longer the protein interacts with Cnx. Mutations in glycoproteins increase their association with Cnx, and these mutant proteins are retained in the endoplasmic reticulum. However, until now, the increased interaction with Cnx was not known to incre...

OBJECTIVE To explore the non-pharmacological correlates of the perceived effectiveness of antidepressants (ADs), thereby enhancing understanding of the mechanisms involved in recovery from depression while taking ADs. METHOD An online survey was completed by 1781 New Zealand adults who had taken ADs in the previous 5 years. RESULTS All 18 psychosocial variables measured were associated with...