The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...

The Standard Model does not provide a very good fit to the most recent precision electroweak data from LEP, due primarily to the observed branching ratios for Z decay to bb̄ and cc̄. The possibility that an extension of the Standard Model with low-energy supersymmetry can improve the agreement between data and theory is considered. Invited Talk at the 1995 International Europhysics Conference on ...

Milk production records of 306 Alpine, 72 LaMancha, 170 Nubian, 84 Saanen, and 235 Toggenburg does born in the Northeast from 1972 through 1979 were used to estimate trends of additive genetic value. Estimated transmitting abilities were doubled and averaged for all does born in each year to obtain yearly estimates of genetic value. Genetic trends from regression of yearly mean genetic value on...

charcot-marie-tooth (cmt) diseases represent a heterogeneous genetic disorder with more than 80 genes implicated, however sharing a similar phenotype. in recent years, advances in molecular genetics and molecular biology, and also the development of various animal models of cmt, have led to a better understanding. this knowledge represents a prerequisite for the development of future therapies ...

The colorectal cancer (CRC) subtyping consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the consensus molecular subtypes (CMS); clinical implications are discussed in this review based on articles relevant to the CMS of CRC indexed in PubMed as well as the authors’ own ...

the use of animal models in modeling of human genetic disease has many advantages. in some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. they ar...

Background and Objectives: Staphylococcus aureus is an important cause of nosocomial and community-acquired infections in every region of the world. Clindamycin is one of the alternative agents used to treat S. aureus infections and accurate identification of clindamycin resistance is important to prevent therapeutic failure. Unfortunately, inducible clindamycin resistance is ...