some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-h-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (viii) have been synthesized from different isatinhydrazones (ii) by condensing with 2-phenyl-5-benzylidene- 3-n (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (vii). their chemical structures have been confirmed by ir, 1hnmr, mass and by elemental analysis. investigation of antimicrobial ac...

The initial step in creatine biosynthesis involves the transfer of an amidine group from arginine to glycine to form guanidinoacetic acid and is catalyzed by the enzyme L-arginine:glycine amidinotransferase (transamidinase). A procedure for the purification of rat kidney transamidinase by chromatography with DEAEcellulose and phenyl-Sepharose is described in this report. Two fractions of enzyme...

Rumen microorganisms rapidly metabolized glycine at rates varying from 0.014 to 0.241 mumole of glycine per ml per min. The main metabolic products were carbon dioxide, acetic acid, and ammonia; little glycine was incorporated into bacterial protein. Use of carboxyl or methylene-labeled glycine showed that the carbon dioxide came mainly from the carboxyl of glycine, whereas both carbons of acet...

Photoresponsive molecular devices can be a valuable tool to promote chemical changes in response multiple signals, such as photons and pH, deliver drugs or detect physiological conditions vivo. For example, trans-chalcones (Ct) from 4′-hydroxyflavylium (F1) 7-hydroxyflavylium (F2) undergo cis-trans isomerization by photoreaction into many different structures. The takes place at slow rate pH ch...

Substance P (SP) and calcitonin gene-related peptide (CGRP) are well established mediators of inflammation. Therefore, inhibition of the biosynthesis of these neuropeptides is an attractive potential strategy for pharmacological intervention against a number of inflammatory diseases. The final step in the biosynthesis of SP and CGRP is the conversion of their glycine-extended precursors to the ...

Glycine is an inhibitory neurotransmitter and is critical for NMDA receptor activation. These roles are dependent on extracellular glycine levels, which are regulated by Na(+)/Cl(-)-dependent glycine transporters (GlyTs) in neurones and glia. The glial GlyT subtype GlyT1 is well located to activate NMDA receptors. However, glial GlyTs have not been studied in an intact system thus far. Whole-ce...