نتایج جستجو برای: philadelphia chromosome
تعداد نتایج: 128365 فیلتر نتایج به سال:
In chronic myelogenous leukemia (CML) and in a percentage of childhood and adult acute lymphoblastic leukemia (ALL) the Philadelphia (Ph’) chromosome is present in the leukemic cells of patients. This chromosome is the result of a reciprocal translocation between chromosomes 9 and 22. In CML the break on chromosome 22 occurs within the major breakpoint cluster region (Mbcr) of the bcr gene. In ...
Case: A 51-year-old man presented with lymphadenopathy and increasing fatigue. He had been diagnosed chronic myeloid leukaemia (CML) seven months earlier a suboptimal response to first line nilotinib, failing achieve MR1 BCR-ABL1/ABL persistently >10% (IS). repeat bone marrow examination showed 90% blasts, consistent CML in blast phase (CML-BP). The blasts monoblastic morphology immunophenotype...
The aim is to determine the epidemiological and cytogenetic profile (Philadelphia chromosome: Ph1) bcr-abl gene in patients with chronic myeloid leukemia (CML) assess therapeutic response of hydroxy-urea Imatinib treatment. From January 1, 2010 December 30, 2020, an observational study for diagnostic analytical purposes was carried out 54 cases CML at National Reference University Hospital (CHU...
BACKGROUND Allogeneic hematopoietic cell transplantation is a potentially curative treatment for patients with acute lymphoblastic leukemia. However, the majority of older adults with acute lymphoblastic leukemia are not candidates for myeloablative conditioning regimens. A non-myeloablative preparative regimen is a reasonable treatment option for this group. We sought to determine the outcome ...
The spatial organization of chromosomes in the nuclear space is an extensively studied field that relies on measurements of structural features and 3D positions of chromosomes with high precision and robustness. However, no tools are currently available to image and analyze chromosome territories in a high-throughput format. Here, we have developed High-throughput Chromosome Territory Mapping (...
The breakpoint regions of both translocation products of the (9;22) Philadelphia translocation of CML patient 83-H84 and their normal chromosome 9 and 22 counterparts have been cloned and analysed. Southern blotting with bcr probes and DNA sequencing revealed that the breaks on chromosome 22 occurred 3' of bcr exon b3 and that the 88 nucleotides between the breakpoints in the chromosome 22 bcr ...
Case report involving a normal female by NIPT with male external genitalia on routine fetal morphology assessment. QF-PCR, CGH microarray, and FISH revealed an unbalanced translocation, involving the short arms of the X and Y chromosomes. This case demonstrates the possible limitations of correctly identifying sex chromosome abnormalities via NIPT.
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