Prior to 1966, almost all available information on drug safety for marketed medicines was strictly qualitative. It was predominantly based on anec-dotal reports and clinical opinions derived primarily from the known pharmacology of particular drugs. While the medical environment for identifying and quantifying drug toxicity was generally informal and undirected, the use of anecdotal reports to ...

We present a Monte-Carlo ion implantation simulation method that allows a very accurate prediction of implantation induced point defects, generation of amorphous areas, and impurity distributions. The implanted impurity pro les can be calculated as well as the distributions of impurities that are moved from one material to another during the implantation process. The simulation method can be ap...

A grand challenge in synthetic biology is to push the design of biomolecular circuits from purely genetic constructs towards systems that interface different levels of the cellular machinery, including signalling networks and metabolic pathways. In this paper, we focus on a genetic circuit for feedback regulation of unbranched metabolic pathways. The objective of this feedback system is to damp...

The thermal behaviour of Hg, -,Mn,Te single crystals is investigated by means of the RBS/channeling technique. The stoichiometry parameter x ranges from 0.08 to 0.2. An important release of Hg atoms is observed after annealing in hydrogen atmosphere at 240 "C for 10 min. Backscattering spectra for crystals with x = 0.2 revealed quite a sharp Hg edge proceeding towards greater depth with increas...

We investigate the adsorption of chlorine on the Cu(111) surface with full potential all-electron density functional calculations. Chlorine adsorption at the fcc hollow sites is slightly preferred over that at the hcp hollow. The adsorption geometry is in excellent agreement with electron diffraction and ion scattering data. Adsorption energies and surface diffusion barriers are close to those ...

BACKGROUND The purpose of this study was to investigate which factors affected the implementation of a multicomponent Responsible Beverage Service (RBS) program in 290 Swedish municipalities and whether the amount of such factors influenced the level of implementation of the program. METHODS This study used variation in the presence of implementation-promoting factors to predict the level of ...

Interest in finding out how many children are handicapped as the result of prenatal influence which might possibly be avoided has increased in recent years, but systems for reporting congenital anomalies have been disappointing. A birth population may sometimes be regarded as well documented because most of the children with anomalies are known to at least one of the various health agencies or ...

Giuseppe Mastrangelo ([email protected]) Gianluca Marangi ([email protected]) Maria N Ballarin ([email protected]) Silvia Michilin ([email protected]) Aline SC Fabricio ([email protected]) Flavio Valentini ([email protected]) John H Lange ([email protected]) Ugo Fedeli ([email protected]) Luca Cegolon (l.ceg...

Reordering Based Synthesis (RBS) as an alternative approach to manipulate Decision Diagrams (DDs) is presented. Based on the concept of operation nodes a single \core" operation, i.e. an extended Level Exchange (LE), is suucient to perform the usual synthesis operations on several types of DDs. RBS allows the integration of dynamic variable ordering (even) within a single synthesis operation (e...

The aim of this work is to investigate the feasibility of ion beam analysis techniques for monitoring swift heavy ion track formation. First, the use of the in situ Rutherford backscattering spectrometry in channeling mode to observe damage build-up in quartz SiO₂ after MeV heavy ion irradiation is demonstrated. Second, new results of the in situ grazing incidence time-of-flight elastic r...