The involvement of the signal transduction pathway in mouse liver following whole body irradition was investigated. Mice were exposed to 60Co gamma rays (3 Gy) and sacrificed after different time intervals. Various elements of phosphatidyl inositol signal transduction pathway were investigated. Alterations could be seen as early as 15 min of irradiation. These changes are reflected in elevation...

The influence of y-hexachlorocyclohexane (HCC) on phosphatidyl inositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. Similar to stimulation by the chemotactic peptide N-formylrile-leu-phe (FNLLP), 125 PM HCC was found to stimulate PI cycle activity, calcium mobilization (4sCa2+ efflux and cytosolic [Cal+] elevation) and 0; production, although the action of HCC wa...

The low-virulence Listeria monocytogenes strains have been previously assigned to 4 phenotypic groups. This study aimed to characterize the A23 strain, which exhibits a pulsed-field gel electrophoresis profile specific to low-virulence strains. This strain has the same causal mutations as the group III strains and a supplementary mutation in the mpl gene, leading to the absence of internalin A ...

The fatty acid composition of phospholipids is an important determinant of membrane function. Although the mitochondria play a pivotal role in skeletal muscle function, the fatty acid composition of their individual phospholipids has not been examined. The purpose of this study was to determine the fatty acid profile of each phospholipid in rat skeletal muscle mitochondria and compare it with t...

The intracellular location of several enzymes concerned with phospholipid metabolism was investigated by examining their distribution in organelles separated on sucrose gradients from total homogenates of castor bean (Ricinus communis var. Hale) endosperm. The enzymes phosphatidic acid phosphatase, CDP-diglyceride-inositol transferase, and phosphatidyletha-nolamine-l-serine phosphatidyl transfe...

This study investigated the roles of low-molecular-weight fucoidan (LMWF) in enhancing anti-cancer effects fluoropyrimidine-based chemotherapy. HCT116 and Caco-2 cells were treated with LMWF 5-FU. Cell viability, cell cycle, apoptosis, migration analyzed both types. Potential mechanisms underlying how enhances chemotherapy also explored. The viability was significantly reduced after treatment a...