Objectives : Drug induced-phospholipidosis is a pathological state caused by repeated administration of cationic amphiphilic drugs. The mechanism of drug-induced phospholipidosis is unclear. Several hypotheses have been proposed, such as inhibition of phospholipase, upregulated phospholipid synthesis, increased uptake of phospholipids, and inhibition of intracellular phospholipid traffic. Among...

sibly occur owing to partial relocation of this phosphatide to apolar sites formerly occupied by the 90 % of major microsomal phospholipid components, which were hydrolysed. Such inhibition should be reversed not only by the phospholipid specifically required by the enzyme in question, but also by others which, re-occupyingapolar sites, wouldreverse relocation of the minor phosphatides. If this...

Microsomal epoxide hydrolase was purified from rat liver, and different fractions of the purified enzyme, which varied in their contents of phospholipid, were obtained by ion-exchange chromatography. One fraction (A), which did not bind to CM-cellulose, had a high phospholipid content, and a second fraction (B), which was eluted from CM-cellulose at high ionic strength, had a low phospholipid c...

Our aim is to investigate the phase segregation and structure of multi-component bioinspired phospholipid vesicles via Dissipative Particle Dynamics. The chemical distinction in the phospholipid species arise due to different head and tail group moeities, and molecular stiffness of the hydrocarbon tails. The individual amphiphilic phospholipid molecular species are represented by a hydrophilic ...

Considerable interest is currently focused on the interactions of beta-2 glycoprotein I (beta2GPI) and anti-phospholipid antibodies with anionic phospholipids in an attempt to understand the association between these antibodies and clinical diseases such as thrombosis. The interactions of beta2GPI and anionic phospholipids have only been characterized partially, and the physiological role of th...

The ABC transporters bile salt export pump (BSEP; encoded by the ABCB11 gene), MDR3 P-glycoprotein (ABCB4), and sterolin 1 and 2 (ABCG5 and ABCG8) are crucial for the excretion of bile salt, phospholipid, and cholesterol, respectively, into the bile of mammals. The current paradigm is that phospholipid excretion mainly serves to protect membranes of the biliary tree against bile salt micelles. ...