Abstract The receptor for activated C kinase 1 (RACK1) adaptor protein has been implicated in viral infection. However, whether RACK1 promotes vivo infection mammals remains unknown. Moreover, it elusive how is engaged antiviral innate immune signaling. In this study, we report that myeloid deficiency does not affect the development and survival of cells under resting conditions but renders mic...

The inhibitors of oxidative phosphorylation induced fragmentation of mitochondria without any signs of apoptosis in CV-1 and HeLa cells. Prolonged treatment with the uncouplers (alone or in combination with the inhibitors of respiration) caused perinuclear clusterization of mitochondria, followed by their selective elimination. The fraction of mitochondria-depleted cells remained viable.

Multisite phosphorylation plays an important role in intracellular signaling. There has been much recent work aimed at understanding the dynamics of such systems when the phosphorylation/dephosphorylation mechanism is distributive, that is, when the binding of a substrate and an enzyme molecule results in the addition or removal of a single phosphate group and repeated binding therefore is requ...

Abstract Oncostatin M Receptor (OSMR) is a key regulator of brain tumour stem cell (BTSC) self-renewal and glioblastoma (GB) tumourigenesis. This receptor found in complex with Epidermal Growth Factor variant III (EGFRvIII) orchestrates positive feedback loop STAT3. OSMR also regulates oxidative phosphorylation participates promoting the transition cells towards mesenchymal-like glioma states. ...