New antibacterial strategies are required in view of the increasing resistance of bacteria to antibiotics. One promising technique involves the photodynamic inactivation of bacteria. Upon exposure to light, a photosensitizer in bacteria can generate singlet oxygen, which oxidizes proteins or lipids, leading to bacteria death. To elucidate the oxidative processes that occur during killing of bac...

Comparison and evaluation of modelled and GOME measurement derived tropospheric NO2 columns over Western and Eastern Europe I. B. Konovalov , M. Beekmann, R. Vautard, J. P. Burrows, A. Richter, H. Nüß, and N. Elansky Institute of Applied Physics, Russian Academy of Sciences, Nizhniy Novgorod, Russia Service d’Aéronomie, Institut Pierre Simon Laplace, Paris, France Laboratoire de Météorogie Dyna...

Photodynamic therapy, unlikely to elicit drug-resistance, deserves attention as a strategy to counter this outstanding problem common to the chemotherapy of all diseases. Previously, we have broadened the applicability of this modality to photodynamic vaccination by exploiting the unusual properties of the trypanosomatid protozoa, Leishmania, i.e., their innate ability of homing to the phagolys...

A novel amphiphilic photosensitizing agent based on a tricationic fullerene C60 (DMC603+) was efficiently synthesized from its non-charged analogue MMC60. These fullerenes presented strong UV absorptions, with broad range of less intense absorption up to 710 nm. Both compounds showed low fluorescence emission and were able photosensitize the production reactive oxygen species. Furthermore, phot...

To overcome the poor water solubility of curcumin, a curcumin-?-cyclodextrin (Cur-?-CD) complex was prepared as novel photosensitizer. Fourier-transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were used to verify formation Cur-?-CD. Furthermore, ROS generation capacity photodynamic bactericidal effect measured confirm this Cur-?-CD kep...

Organic photosensitizers can facilitate photochemical singlet-oxygen ( 1 O 2 ) production, providing a promising strategy for photocatalysis, photodynamic therapy, and environmental protection. Unfortunately, most organic tend to self-aggregate because of their hydrophobicity conjugated ?–? electronic structure, leading the inactivation photosensitizing capabilities. Thus, controlled aggregatio...