PURPOSE To use histological techniques to assess and compare the ablation depth, local damage, and surface quality of corneal ablations by a Q-switched Er:YAG laser, an optical parametric oscillator laser at 2.94 microm, a long pulse Er:YAG laser, and a 193-nm excimer laser. METHODS Human cadaver eyes and in vivo cat eyes were treated with a 6.0-mm diameter, 30-microm-deep phototherapeutic ke...

PURPOSE To describe a topographically guided photorefractive keratectomy technique for the management of secondary hyperopia following radial keratectomy. METHODS A retrospective study was carried out in patients where a topographically guided photorefractive keratectomy technique was performed for the management of secondary hyperopia following radial keratectomy. The patients had preoperati...

A facile supramolecular approach to prepare surface functionalized silver nanoparticle conjugates has been established and their enhanced molecular recognition features have been explored to demonstrate the uptake and stimulus responsive release of a phototherapeutic porphyrin dye, the TMPyP.

PURPOSE To compare changes in the corneal wavefront aberrations after photorefractive keratectomy and laser in situ keratomileusis. METHODS In a prospective randomized study, 22 patients with bilateral myopia received photorefractive keratectomy on one eye and laser in situ keratomileusis on the other eye. The procedure assigned to each eye and the sequence of surgery for each patient were ra...

In the last two decades, corneal laser surgery has become a common procedure to correct medium-low refractive defects. It consists of reshaping geometry by means in order present error. this work, we compare opto-mechanical performance procedures: Photorefractive Keratectomy (PRK) and Small Incision Lenticule Extraction (SMILE).

Amphiphilic-like carbon dots bearing ionizable carboxylate groups and hydrophobic alkyl chains entrap molecules solubilize them in aqueous systems. In nanomedicine they can be used as drug delivery systems phototherapeutic agents.

We sought to determine if connective tissue growth factor (CTGF) is necessary for the formation of corneal haze after corneal injury. Mice with post-natal, tamoxifen-induced, knockout of CTGF were subjected to excimer laser phototherapeutic keratectomy (PTK) and the corneas were allowed to heal. The extent of scaring was observed in non-induced mice, heterozygotes, and full homozygous knockout ...

PURPOSE To determine the in vivo efficacy and safety of a retroviral vector bearing an antiproliferative dominant negative mutant cyclin G1 (dnG1) construct, when used for the prevention of corneal haze after phototherapeutic keratectomy (PTK). METHODS For in vivo efficacy studies, a 6-mm-diameter, 150-microm-deep transepithelial PTK, performed with a clinical 193-nm ArF excimer laser (VISX S...