Chronic pain is commonly treated by prescribing an opioid medication. For those suffering from both chronic pain and substance dependence, barriers to adequate pain management increase. This often causes both disorders to exacerbate one another. Effective treatment may also be hampered by opioid-induced hyperalgesia, tolerance, physical dependence, "chemical coping," and diminished physical and...

Previous pharmacological studies have implicated serotonergic brain systems in opiate withdrawal syndrome. Increased brain 5-HT release is associated with the development of physical dependence to morphine. Specific serotonin reuptake inhibitors, such as fluvoxamine and sertraline reduce the severity of naloxone precipitated opioid withdrawal syndrome. Other studies have shown that 5-HT system ...

Material-spatial interdependence (mat-dep) is a type of dependence in which the physical extents of two entities are necessarily and mutually contingent, e.g. an object and its matter, or a hole and its host. Such dependence is commonly found amongst arrangements of physical entities, particularly in models of the natural environment. In this paper, we analyze and formally characterize mat-dep,...

The distribution of norepinephrine, dopamine and 5-hydroxytryptamine in various areas of the CNS of the normal monkey has been presented. The central levels and distribution of norepinephrine, dopamine and 5-hydroxytryptamine were determined after single doses of morphine, during maintenance of physical dependence and following withdrawal from chronic administration of morphine. Small and non-s...

Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge. Dependence also developed in mice rendered tolerant to morphine. Thus, the development of morphine dependence was observed in the absence and presence of tolera...

Recent data suggest that opioid receptors are involved in the development of nicotine physical dependence in mammals. Evidence in support of a similar involvement in an invertebrate (Planaria) is presented using the selective opioid receptor antagonist naloxone, and the more receptor subtype-selective antagonists CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) (μ, MOR), naltrindole (δ, DOR), and...

The frequency of homologous recombination is believed to be a linear function of the length (N bp) of homology between DNAs. Here, the N intercept is believed to be determined by a threshold length below which some physical constraint is effective. In the mammalian gene targeting systems, however, the frequency depends more steeply than linearly on the homology length. To explain both the linea...

Previous pharmacological studies have implicated serotonergic brain systems in opiate withdrawal syndrome. Increased brain 5-HT release is associated with the development of physical dependence to morphine. Specific serotonin reuptake inhibitors, such as fluvoxamine and sertraline reduce the severity of naloxone precipitated opioid withdrawal syndrome. Other studies have shown that 5-HT system ...

conclusions metacognitive regulation strategies are more considerable prediction than emotional regulation strategies in sd group than in ad group. individuals with ad use alcohol as a means of both cognitive and emotional regulation strategy. patients and methods according to dsm-iv tr criteria, 45 patients with alcohol dependence (ad), 44 patients with substance dependence (sd), and 43 volunt...

conclusions opium was not identified as a risk factor of ischemic stroke. a more extended survey considering further confounding factors is recommended. background one of the supposed risk factors of ischemic stroke is opium addiction, while the researches about its prevalence among patients with stroke are limited. objectives the aim of this study was comparing the prevalence of opium addictio...