1 DDS; Address: Av. Raja Gabaglia, 1000 / 1209 – Gutierrez – Belo Horizonte, MG – 30441-070 – Brazil. [email protected] +55 31 91625090 +55 31 32920997 2 DDS, Oral and Maxillofacial Surgeon, MS in Oral and Maxillofacial Surgery, PhD in Oral and Maxillofacial Surgery (Eastman Dental Institute, University College London). Address: Pontifícia Universidade Católica de Minas Gerais, Depart...

Acute renal failure (ARF) is an independent risk factor associated with increased mortality during sepsis. Recent consensus definitions have allowed the standardization of research on the subject. The understanding of the physiopathology of ARF during sepsis is limited by the scarcity of histological studies and the inability to measure renal microcirculatory flows. Historically, ARF during sep...

Recent epidemiological surveys have demonstrated an important increase in nosocomial infections among which Candida sp. plays an increasingly prominent role. Candida is now involved in about 10% of all septicemia and leads to a very high mortality rate in immunodepressed patients. Clinical studies show that any modification of the host immune status can facilitate the proliferation of endogenou...

Since the tau protein is closely involved in the physiopathology of Alzheimer's disease (AD), studying its behavior in cellular models might lead to new insights on understanding this devastating disease at molecular levels. In the present study, primary cultures of human fibroblasts were established and used to determine the expression and localization of the tau protein in distinct phosphoryl...

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, including memory loss, behavioral and psychological symptoms and personality changes. The neuropathological hallmarks of AD are the presence of neuritic (senile) plaques (NP) and neurofibrillary tangles (NFT), along with neuronal loss, dystrophic neurites, and gliosis. Neuritic plaques are ex...

OBJECTIVE: To review the literature on the hypoxic-ischemic syndrome, emphasizing its physiopathology, clinical manifestations, and treatment. SOURCES: Electronic search in the Medline and LILACS databases, with selection of the most relevant articles. SUMMARY OF THE FINDINGS: The hypoxic-ischemic syndrome is a multisystem disease with generalized manifestations. The physiopathology is based on...

RFO, Passo Fundo, v. 18, n. 1, p. 101-106, jan./abr. 2013 Introduction: osteoradionecrosis (ORN) of facial bones is a serious complication of radiotherapy. Objective: this literature review was performed to study maxillary osteoradionecrosis, its incidence, classification, risk factors, physiopathology, prevention, and current treatment. Literature review: literature search using Medline was pe...

The recent Zika virus (ZIKV) epidemic has highlighted the poor knowledge on its physiopathology. Recent studies showed that ZIKV of the Asian lineage, responsible for this international outbreak, causes neuropathology in vitro and in vivo. However, two African lineages exist and the virus is currently found circulating in Africa. The original African strain was also suggested to be neurovirulen...

A consensus has recently emerged that further progress in understanding human physiopathology will demand integrative views of biological systems. In this context, complex systems and related interdisciplinary approaches of biology are expected to help. The aim of this collective paper is basically to provide a starting point for further discussions and interactions within the community of comp...

There is a growing body of evidence that neural stem cells reside in the adult central nervous system where neurogenesis occurs throughout lifespan. Neurogenesis concerns mainly two areas in the brain: the subgranular zone of the dentate gyrus in the hippocampus and the subventricular zone, where it is controlled by several trophic factors and neuroactive molecules. Neurogenesis is involved in ...