Recent work suggests neurons can have different types of GABAA receptors that mediate phasic inhibitory post-synaptic currents (IPSCs) and tonic currents. This study examines the diversity of GABAergic synaptic currents in parasympathetic cardioinhibitory neurons that receive rhythmic bursts of GABAergic neurotransmission. Focal application of gabazine (25 μM) to cardiac vagal neurons in-vitro ...

Many inhaled anesthetics enhance the effect of the inhibitory neurotransmitter gamma aminobutyric acid (GABA), supporting the view that the GABAA receptor could mediate the capacity of inhaled anesthetics to produce immobility in the face of noxious stimulation (i.e., MAC, the minimum alveolar concentration required to suppress movement in response to a noxious stimulus in 50% of subjects). How...

BACKGROUND Estradiol and progesterone as well as hippocampal GABA(A) receptors are believed to play a role in the modulation of pain. The aim of present study was to investigate the effect of intrahippocampal injections of GABA(A) receptor agonist (muscimol) and GABA(A) receptor antagonist (picrotoxin) on pain sensitivity during estrous cycle. METHODS Pain sensitivity was evaluated in rats by...

A capacitance sensor which detects vibrations caused by the movements of animals can be used for measuring automatically the clonic convulsions induced by chemical convulsants. This knowledge has been utilized to devise an instrument which has satisfactorily measured the clonic convulsions induced by picrotoxin in rats.

1 1 2 3 4 Title: Cerebellar cortex contributions to the expression and timing of 5 conditioned eyelid responses. 6 7 Abbreviated title: Cerebellar cortex and eyelid conditioning 8 9 Authors: Brian E. Kalmbach, Tobin Davis, Tatsuya Ohyama, Frank Riusech, 10 William L. Nores and Michael D. Mauk 11 Center for Learning and Memory 12 Section of Neurobiology 13 University of Texas Austin 14 1 Univers...

The frequent coexistence of depression in epileptic patients raises the issue of simultaneous use of antidepressants along with antiepileptic drugs in the management of such cases. However, it is necessary to evaluate the safety of these antiepileptic/antidepressant drug combinations. The present study investigates the effect of the antidepressant paroxetine (a selective serotonin reuptake inhi...

Activation of the dopaminergic (DA) neurons of the ventral tegmental area (VTA) by ethanol has been implicated in its rewarding and reinforcing effects. We previously demonstrated that ethanol enhances GABA release onto VTA-DA neurons via activation of 5-HT2C receptors and subsequent release of calcium from intracellular stores. Here we demonstrate that excitation of VTA-DA neurons by ethanol i...