Objective: The purpose of this article is to review the literature assessing foetal and maternal pregnancy outcomes in women with PCOS who used metformin during pregnancy. Study Design: A literature search was conducted using MEDLINE, with analysis of 25 studies that recorded neonatal and maternal outcomes in women who used metformin during pregnancy. The outcomes assessed in this review includ...

Essential hypertension (EH) accounts for 80-90% of hypertension, and pregnancy-induced hypertension (PIH) is responsible for hypertension during pregnancy. Both considered multifactorial disorders. While both have many features in common, conditions and causes of these diseases have yet to be clarified. Since both diseases are associated with hypertension, the genetic backgrounds may contain co...

Placement of lumboperitoneal (LP) shunt as a surgical treatment for benign intracranial hypertension (BIH) is generally a safe procedure, with complications like mechanical failure, overdrainage and infections. Subarachnoid hemorrhage and intracerebral hematoma were seen after lumboperitoneal shunt in a patient having BIH. These complications were the cause of the patient's deterioration. After...

Background: This study aimed to investigate the effects of abnormal placental location and placenta accreta spectrum (PAS) disorder on risk hypertensive disorders pregnancy (HDPs). Methods: retrospective included 985 patients with 2100 normal location. The incidence HDPs in those concurrent PAS was analyzed. factors affecting pregnancy-induced hypertension (PIH) were analyzed using logistic reg...

S 969 Marchiafava disease, i.e. PNH. When this is disregarded. the disease may remain unrecognized for a long time, until the typical syndrome of paroxysmal nocturnal hemoglobinuria becomes apparent. In some cases the disorder begins with thrombocytopenic purpura (TP), s hile the typical PIH appears several years (in one female patient 12 yr) after the removal ofthe spleen for TP. In other case...

The R2TP cochaperone complex plays a critical role in the assembly of multisubunit machines, including small nucleolar ribonucleoproteins (snoRNPs), RNA polymerase II, and the mTORC1 and SMG1 kinase complexes, but the molecular basis of substrate recognition remains unclear. Here, we describe a phosphopeptide binding domain (PIH-N) in the PIH1D1 subunit of the R2TP complex that preferentially b...

Long asters rock the spindle M itotic cells regulate the lengths of their astral microtubules to keep the spindle steady during cytokine-sis, Rankin and Worde-man report. Astral microtu-bules emanate from the spindle poles toward the cell cortex and help to position the cleavage furrow at the end of mitosis by confi ning actomyosin contraction to the cell equator: when microtubules are shortene...

An apparent high molecular weight angiotensinogen (H-Aogen) can be separated from the usually predominant low molecular weight angiotensinogen (L-Aogen) by gel filtration of plasma. H-Aogen has been quantitated in plasma from normotensive menstruating women, estrogen treated women, normotensive pregnant women, women with pregnancy-induced hypertension (PIH), and women whose preexisting hyperten...