Piper nigrum (P. nigrum) is commonly used in traditional medicine. This current study aimed to investigate the anticancer and cancer preventive activity of a piperine-free P. nigrum extract (PFPE) against breast cancer cells and N-nitrosomethylurea (NMU)-induced mammary tumorigenesis in rats. The cytotoxic effects and the mechanism of action were investigated in breast cancer cells using the MT...

PURPOSE Piperine, a major alkaloid of black pepper (Piper nigrum) and long pepper (Piper longum), was shown to have anti-inflammatory activity through the suppression of cyclooxygenase (COX)-2 gene expression and enzyme activity. It is also reported to exhibit anti-platelet activity, but the mechanism underlying this action remains unknown. In this study, we investigated a putative anti-platele...

INTRODUCTION Trikatu is composed of dried fruits of Piper nigrum L and Piper retrofractum Vahl, and dried rhizomes of Zingiber officinale R. Although this preparation has been used to relieve pruritis, pain, and inflammation for a long time, there is no clinical evidence to confirm its efficacy and safety. Therefore, we performed a double-blind, within person-randomized controlled study of 30 h...

Malay traditional medicine practice concentrates on the primary healthcare including physical and spiritual aspects of human being. Most traditional practitioners use medicinal plants in the treatment. Hence, the study is aimed to compile preparations and local medicinal plants used traditionally by the women in postnatal care. Five Malay traditional practitioners based in the district of Muar ...

Piperine is a major pungent substance and active component of black pepper (Piper nigrum Linn.) and long pepper (Piper longum Linn.). Regarding the variable biological activities of piperine, it is important to study its antimutagenic activity in somatic and germ cells in vivo. Swiss albino male mice were orally administered piperine at the doses of 5, 10 and 15mg/kg b. wt. for three consecutiv...

This study focused on the development of gelatin-based films with incorporation of microcrystalline cellulose as reinforcement material. Clove (Syzygium aromaticum), nutmeg (Myristica fragrans), and black pepper (Piper nigrum) oleoresins containing antimicrobial compounds of natural origin were incorporated into the films. The mechanical, thermal, optical, and structural properties, as well as ...

Aedes aegypti is the primary vector of chikungunya, yellow and dengue fevers. Dengue fever is the major cause of child morbidity and hospitalisation in some Asian and African countries, while yellow fever is prevalent in Nigeria. The development of resistance to the available insecticides has necessitated the continued search for safer ones from plants. Eighteen plant extracts with ethnomedical...

Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prev...

There are various human diseases caused by Vibrio species which are pathogenic in nature these diseases are mainly water-borne. In this case “To Study the Therapeutic Role of Indian Spices In The Treatment Of Gastrointestinal Disease Caused By Vibrio Species”. I have chosen fifteen types of Indian spices which are as follows Amomum subulatum, Brassica nigra, Capsicum annuum, Cinnamomum tamala, ...

Food nutrients having antioxidant potential have been a major focus of research in recent years because they were regarded as magic bullets that could help to prevent many human diseases such as cancer, arthritis, Alzheimer, Parkinson and cardiovascular diseases, etc. In the present research, the four plants namelytea (Camellia sinensis), ginger (Zingiber officinale), black pepper (Piper nigrum...