OBJECTIVE To evaluate perinatal outcomes and congenital heart defect (CHD) prognosis in a non-selected population. METHODS The population-based surveillance data used in this assessment of CHDs were based on birth defect surveillance data collected from 2010-2012 in Liuyang City, China. Infants living with CHDs were followed up for 5 years to determine their prognosis. Prevalence, prenatal di...

We have examined the kinetics of the inhibition of human immunodeficiency virus type 1 (HIV-1) particle infectivity by protease inhibitors (PIs) in cell culture, using either transfected HeLa cells or infected peripheral blood mononuclear cells (PBMCs) as producers of infectious virions. Both the kinetics of the initiation of antiviral activity after addition of the PIs to these cultures and th...

The present study was carried out to assess the effects of protease inhibitor (PI) therapy on basal whole body protein metabolism and its response to acute amino acid-glucose infusion in 14 human immunodeficiency virus (HIV)-infected patients. Patients treated with PIs (PI+, 7 patients) or without PIs (PI-, 7 patients) were studied after an overnight fast during a 180-min basal period followed ...

We previously showed that human and murine 3T3-F442A preadipocytes produced and released matrix metalloproteinases (MMPs) 2 and 9 and that a treatment by MMP inhibitors resulted in the blockade of murine fat cell adipose conversion. In parallel, investigators reported that other protease inhibitors, the human immunodeficiency virus (HIV) protease inhibitors (PIs) involved in lipodystrophy in hu...

Submitted 2 Proteasome inhibitors in experimental therapeutics of autoimmune diseases Submitted 28 Abstract Current treatment strategies for rheumatoid arthritis (RA) consisting of disease modifying antirheumatic drugs or biological agents are not always effective , hence driving the demand for new experimental therapeutics. The anti-proliferative capacity of proteasome inhibitors (PIs) has rec...

The intermittency of renewable energy will increase the uncertainty of the power system, so it is necessary to predict the short-term wind power, after which the electrical power system can operate reliably and safely. Unlike the traditional point forecasting, the purpose of this study is to quantify the potential uncertainties of wind power and to construct prediction intervals (PIs) and predi...

Methods Inf Med 2015; 54: 379–381 http://dx.doi.org/10.3414/ME15-04-0003 received: March 6, 2015 accepted: May 29, 2015 epub ahead of print: June 25, 2015 * Supplementary online material published on our website www.methods-online.com Dear Editor, The main aim of this brief communication was to highlight how automatic methodologies are useful in the process of optimization of medicinal package ...

Purpose: Pharmacist-led medication reviews in hospitals have shown improvement in patient outcomes. The aim of this study is to describe the prevalence and nature of pharmacist interventions (PIs) following a medication review in an Irish teaching hospital. Methods: PIs were recorded over a six-month period in 2015. PIs were assessed by a panel of healthcare professionals (n = 5) to estimate th...

Pervasive Information Systems (PIS) constitute an emerging class of Information Systems where Information Technology is gradually embedded in the physical environment, capable of accommodating user needs and wants when desired. PIS differ from Desktop Information Systems (DIS) in that they encompass a complex, dynamic environment composed of multiple artefacts instead of Personal Computers only...

HIV(+) subjects on optimal antiretroviral therapy have persistently impaired antibody responses to pneumococcal vaccination. We explored the possibility that this effect may be due to HIV protease inhibitors (PIs). We found that in humans and mice, PIs do not affect antibody production in response to pneumococcal vaccination.