BACKGROUND The existence of pituitary stem cells in the adult pituitary gland is supported by such findings as postnatal proliferation, differentiation based on environmental alterations, and development of hormone-producing cells after specific lesions in the pituitary. OBJECTIVE We discuss which cells in the adult pituitary gland might play a role as pituitary stem cells, the potential for ...

Pituitary stimulation with pulsatile gonadotropin-releasing hormone (GnRH) analogs induces both follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Pituitary gonadotropin secretions are blocked upon desensitization when a continuous GnRH stimulus is provided by means of an agonist or when the pituitary receptors are occupied with a competitive antagonist. GnRH antagonists were not ...

Thyroid hormone (T3 and T4) is secreted from the thyroid gland, and is known to reduce the level of serum thyrotropin (thyroid-stimulating hormone, TSH) in the pituitary gland (Sarapura et al., 2002; Shupnik et al., 1989) (Fig. 1A). This is a typical example of negative feedback between the pituitary and endocrine organs, and is a key component of thyroid hormone homeostasis. TSH is one of the ...

Objectives: To determine whether hormonal dysfunction involving the hypothalamic-pituitary-adrenal (HPA) axis, prolactin (PRL) secretion, and sex hormone status contribute to development of systemic lupus erythematosus (SLE). Methods: 11 patients with SLE and 9 healthy controls were tested for their total anterior pituitary gland reserve by simultaneous injection of corticotropin-, growth hormo...

We report a case of pituitary adenoma with normal hormone levels in 34-year-old female. She presented to OP headache, milky discharge from nipples and secondary amenorrhea transient loss vision. Patient had hyperprolactinemia all other hormones. MRI revealed space occupying lesion sellar suprasellar region. Neurological consultation suggested Rathke’s cyst/ craniopharyngioma/ macroadenoma. Exci...

pathological hormone secretion, the clinical presentation is determined by localization of tumor. Common symptoms include headache and visual field defects. This review addresses pathology aspects diagnosis, conservative treatment, methods radiation therapy. Drug therapy endocrine-inactive adenomas based on presence receptors for somatostatin dopamine in pituitary adenoma cells. Data stereotact...

A 34-year-old woman suffered from palpitation, easy sweating, heat intolerance, increased appetite, irregular menstrual cycle and hand tremor for 1 year. Thyroid function tests showed elevated serum thyroxine (T4), tri-iodothyronine (T3) and thyrotropin (TSH). Computerized tomography (CT) revealed pituitary tumor with supraseller extension. Thyrotropin releasing hormone (TRH) test showed blunte...

IT is now more than 40 years since Evans and Long first demonstrated the growthpromoting activity of crude extracts prepared from the anterior pituitary. Since then the hormone responsilble has been extracted from the pituitary glands and purified. It has been shown to be a polypeptide and important differences have been demonstrated between growth hormones from different species. Bovine growth...

BACKGROUND We investigated the prevalence of electrolyte imbalance and the relationship between serum electrolyte and anterior pituitary hormone levels in patients with Sheehan's syndrome. METHODS In a retrospective study, we investigated 78 patients with Sheehan's syndrome. We also included 95 normal control subjects who underwent a combined anterior pituitary hormone stimulation test and sh...

1. Human growth hormone was prepared from acetone-dried residues after extraction of gonadotrophins from pituitary glands. 2. Crude growth hormone was purified by gel filtration on Sephadex, resulting in a product that is soluble in water or 0.5% sodium chloride. It is painless on injection and shows a twofold increase in biological potency. Aggregation of growth hormone on Sephadex columns can...