Abstract Objectives To rule out a drug-drug interaction (DDI) among cangrelor-treated patients who have been pre-treated with ticagrelor. Background There are no studies specifically designed to DDI when cangrelor is used Methods In this prospective, randomized, double-blind, placebo-controlled, cross-over, pharmacokinetic (PK) and pharmacodynamic (PD) study, coronary artery disease (n = 20) we...

Abstract Background Anterior uveitis (AU) is the most frequent extra-articular feature of axial spondyloarthritis (axSpA). We aimed to assess and compare incidence AU in axSpA patients treated with anti-TNF or anti-IL17A. Methods systematically reviewed PubMed, EMBase, Cochrane from inception May 3, 2020, searched for placebo-controlled head-to-head randomized controlled trials (RCTs) assessing...

Background: Emergence delirium (ED) is a complication after surgeries due to general anesthesia. Objectives: This study aimed evaluate the efficacy of melatonin and clonidine, which are hypothesized have curative effect on ED. Methods: randomized, placebo-controlled, double-blind, three-way parallel clinical trial was performed in Imam Reza Hospital Birjand, Iran 2019 - 2020 who were selected u...