background : due to symptoms and its complications, menopause influences the mental, psychological and physical health, social performance and familial relationships. because of the undesirable side effects of hormone replacement therapy, tendency and desire toward alternative treatments in relieving menopausal symptoms have increased. among the alternative therapies are herbs and among those, ...

conclusions the study demonstrated that 1000 iu vitamin d supplementation for 3 months can decrease the insulin resistance in individuals with prediabetes; however, it has no significant effect on body fat mass percentage. background low serum levels of vitamin d are supposed to contribute to the incidence of diabetes; therefore, vitamin d supplementation may reduce the incidence of diabetes in...

abstract   objective: to determine the effect of oral zinc sulfate supplementation given with coamoxiclav when compared with coamoxiclav alone for treatment of otitis media with effusion (ome). the efficacy of the drug was assessed 3 and 6 weeks after administration .   methods: in a double-blind, randomized trial 4 to 14 years old children with ome who referred to ear, nose and throat clinic, ...

OBJECTIVE To carry out a metaanalysis of antidepressant studies to calculate the effect sizes for antidepressant effect in depressive disorder. METHOD A metaanalysis of all antidepressant studies that included an active comparison drug as well as placebo was used to calculate the effect size. Articles were selected from a MEDLINE search for the period January 1966 to June 1995. Forty-nine stu...

OBJECTIVE To determine the placebo component of treatment responses in patients with intellectual disability (ID). METHODS A statistical meta-analysis comparing bias-corrected effect sizes (Hedges g) of drug responses in open-label vs placebo-controlled clinical trials was performed, as these trial types represent different certainty of receiving genuine treatment (100% vs 50%). Studies in fr...