BACKGROUND The unique immunobiology of the placental trophoblast and the increased incidence of hemangiomas in infants born after chorionic villus sampling suggest that an immunologically regulated ectopic focus of trophoblasts could be the cell of origin for proliferative infantile hemangiomas. OBJECTIVE To compare tissue from infantile hemangiomas with that of other vascular lesions for the...

The vasodilator-stimulated phosphoprotein (VASP) is a 46 kDa protein present at the leading edge of migrating cells. Because trophoblastic cell migration and invasion are critical stages for the achievement of successful implantation and development of the placenta, we investigated VASP expression in different cell types of the human placenta throughout pregnancy by immunohistochemistry and Wes...

A 20-year-old male presented with persistent right testicular pain. Following ultrasound detection of testicular nodules and biopsy for intraoperative consultation which yielded germ cell tumour, he underwent radical orchidectomy. A predominantly whitish cyst and a lobulated, variegated nodule were identified. Histology showed a mature cystic teratoma with a focus of infiltrative epithelioid ce...

BACKGROUND Gestational trophoblastic neoplasia (GTN) is a malignant disease which occurs in women of reproductive age. Treatment of GTN has an excellent outcome and further pregnancies can be expected. However, data concerning quality of life in these cancer survivor patients are limited. This study aimed to assess quality of life in women who were diagnosed with GTN and remission after treatme...

BACKGROUND Gestational trophoblastic neoplasia (GTN) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. Even in its metastatic forms GTN is curable with a cure rate of 90-100 %. Currently, methotrexate with or without folic acid, andactinomycin D is recommended for low risk GTN. The aim of this study is to compare the efficacy of methotrexate and actino...

BACKGROUND AND INTRODUCTION Gestational trophoblastic disease (GTD) is a disease of the proliferative trophoblastic allograft. Diagnosis and treatment of GTN in low resource-income countries is challenging due to numerous factors. The objective of this study was to review outcomes of gestational trophoblastic neoplasia in women of low socioeconomic status with limited resources and social suppo...

http://dx.doi.org/10.1016/j.ebiom.2016.01.013 2352-3964/Crown Copyright © 2016 Published by Elsevie Gestational trophoblastic diseases (GTD) are a group of disorders that originate from the trophoblast, which is the outer layer of the blastocyst that normally gives rise to the placenta and is the first tissue to differentiate from the developing embryos after implantation. The human chorionic g...

OBJECTIVE To analyse the results of our conservative management of retained trophoblastic tissue and placental polyp with diagnostic ambulatory hysteroscopy and to describe our experience and guidelines. STUDY DESIGN Descriptive retrospective study. Eighty-four women with suspected retained trophoblastic tissue after pregnancy underwent hysteroscopic examination and extraction of all residual...

This study is aimed at answering whether aging/health-related web sites of different domain extensions (i.e. .com, .edu, .gov and .org) differ in their accessibility and usability, and whether these two measures are correlated. The usability and accessibility of governmental, organizational, educational and commercial aging/health-related web sites were compared using two automatic evaluation t...

For the past 2-1/2 years, our Research Work Unit (RWU) has been operating a Web site (http://www.se4702.forprod.vt.edu). The site became operational in October 1995. In the beginning, it was primarily designed to stake out a piece of the Internet with our name and our RWU’s organizational mission. Quickly, it became apparent to us, however, that our user community could benefit greatly if we in...