Eleven male patients with genital warts were given injections of fibroblast interferon (300 u) and placebo into the bases of two similar warts. The changes in size of the treated warts compared with that of the controls suggested that interferon did inhibit the growth of the warts. The dose given was probably insufficient for a dramatic effect. In one patient, however, a wart on the penile shaf...

Anogenital warts are caused by infection with HPV. There are >100 of these double-stranded-DNA papovaviruses characterised, with most now fully DNA-sequenced. HPV is transmitted sexually in most cases but can also be transmitted prenatally, by auto-inoculation or hetero-inoculation from non-genital warts. Anogenital warts have a 60% transmission rate between partners. Over 95% of genital warts ...

HPV: Human papillomavirus INTRODUCTION Common cutaneous warts caused by human papillomavirus (HPV) strains 1, 2, and 4, can be challenging to treat. Immunosuppressed patients are especially vulnerable to this infection, and the warts may cause physical and psychologic distress. There are currently 3 commercially available vaccines in the United States that target HPV strains commonly associated...

BACKGROUND Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describ...

Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase. Here, we use Phos-tag gels to characterize Warts-dependent phosphorylation of Yki in vivo, and show that Warts promotes phosphorylation of Yki at multiple sites. We also show that Warts inhibits Yki nuclear localization in vivo, and can promote binding of Yki to 14-3-3 prot...

BACKGROUND Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium hydroxide is a strong...

Background: A safe, simple, effective method of treating warts is needed. Objectives: To evaluate 1) safety of candida antigen injections for the treatment of common warts, 2) patient satisfaction with the treatment. Methods: Chart review and telephone follow-up of 149 patients treated for common warts by intradermal and intralesional candida antigen injections. Results: 104 were reached by tel...

The mitotic apparatus plays a pivotal role in dividing cells to ensure each daughter cell receives a full set of chromosomes and complement of cytoplasm during mitosis. A human homologue of the Drosophila warts tumor suppressor, h-warts/LATS1, is an evolutionarily conserved serine/threonine kinase and a dynamic component of the mitotic apparatus. We have identified an interaction of h-warts/LAT...

OBJECTIVE To assess whether anogenital warts, present or past, are an indication for women to be referred for colposcopy. DESIGN A case control study comparing patients with and without a history of anogenital warts. SETTING A department of genitourinary medicine in West London. PATIENTS 468 patients examined by colposcopy between January 1985 and December 1987 of whom 147 (31%) had abnor...

Background: Human papillomavirus (HPV) is a large group of DNA viruses that cause skin and mucosal warts. Zinc is used in the treatment of skin diseases. Zinc has been used in the treatment of various skin and systemic diseases. Warts are benign proliferation of the skin and mucosa. The prevalence of skin warts is higher in children and its peak is in adolescence and then decreases with age. So...