Primary non-secretory Plasma cell leukemiaisa rare diagnosis with only few cases reported so far. Here we report a case of a non secretory Plasma cell leukemia diagnosed on flow cytometry, as atypical morphology and negative serum and urine protein electrophoresis made it difficult to come to a conclusive diagnosis based on morphology.

Radiogenic myeloid leukemia of the RF mouse was passaged in unirradiated newborn and adult recipients of the same strain by intravenous inoculation of leukemic spleen cell suspensions, cell-free filtrates of such suspensions, and centrifuged (presumably cell-free) spleen extracts and blood plasma. The incidence of leukemia in inoculated mice increased on successive passages, and the induction p...

purpose: to report an unusual ocular presentation of a relapse of acute lymphoblastic leukemia. case report: a 9-year-old girl presented with a subconjunctival mass and ipsilateral preauricular lymphadenopathy. she had history of acute lymphoblastic leukemia (all) in remission but had a normal blood cell profile. because of corneal dellen formation and enlargement of the mass over a 2-week peri...

Two IgM monoclonal antibodies (MAb) with strong reactivity for granulocytes and to a lesser extent for lurkat cell lines were established by immunizing BALBI c mice with a histiocytic cell line (UY37). These two MAbs (designated as 6C9 and 4C4) reacted with blast cells of T-acute lymphoblastic leukemia (T-ALL) and acute myelogenous leukemia (AML) patients as well as leukemic cells from pat...

fab (french – american- british) group determined a diagnostic classification for leukemia's. but in spite of some reports on different clinical findings and prognosis of hmc and lgl there is no place for hand- mirror cell leukemia and lgl leukemia in this classification. on the other hand, there are different ideas about causes of hand mirror cell and about different changes of large granlar l...

abstract leukemia is known as the world’s fifth most prevalent cancer. new cytotoxic drugs have created considerable progress in the treatment, but side effects are still the important cause of mortality. plant derivatives have been recently considered as important sources for the treatment of various diseases, including cancer. gallic acid (ga) is a polyhydroxyphenolic compound with a wide ran...

the study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. the processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only a mi...

background: benzene is one of the important occupational pollutants. there are some reports about the leukemogenic effects related to low-level exposure to benzene. objective: to study the frequency of micronucleus (mn), nucleoplasmic bridge (nb), and nuclear budding (nbud) in the peripheral blood lymphocytes of petrochemical workers with low level exposure to benzene. methods: we enrolled 50 w...

The plasma soluble interleukin-2 receptor (sIL-2R) level was higher in 137 patients with acute leukemia (1,489 +/- 1,798 U/ml, including 98 cases of acute myeloid leukemia (AML), 1,063 +/- 1,414 U/ml, and 39 cases of acute lymphoblastic leukemia (ALL), 2,561 +/- 2,194 U/ml), compared to 49 normal control subjects, 421 +/- 151 U/ml). The ALL patients showed elevated plasma sIL-2R levels more fre...

introduction: leukemia is a malignant disorder resulting from clonal proliferation of lymphoid or myeloid precursors with arrested maturation. it has been shown recently that telomers and telomerase activity are involved in the control of cell proliferation, regulation of cell senescence in the most somatic cells, and unlimited proliferation capacity of the malignant cells including leukemic ce...