We have recently shown that cardiolipin (CL) and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. In this study, we investigate the immunoreactivity to CL derivatives occurring during endothelial apoptosis in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). We compared the serum immunoreactivity to ...

Albumin is a globular protein of plasma mammalian blood participating in transport hydrophobic metabolites and drugs. Thus, studies devoted to its binding are valuable as part evaluation new potential drugs or fluorescent probes for vivo usage. Here we describe results concerning synthesis bovine serum albumin assay both silico (docking) vitro (spectrophotometric spectrofluorimetric titrations)...

the experimental studies of methane conversion to higher hydrocarbons and methanol using a dielectric barrier discharge (dbd) reactor are presented in this article. the process is carried out at ambient atmospheric pressure and temperature. the dbd reactor is stimulated by an alternative voltage of 50 hz and amplitude of max.23kv. the examination of the effect of voltage and flow rates on metha...

in this paper, construction of triplet atmospheric plasma jet using argon, air, oxygen and nitrogen gases is reported. bactericidal effect of the plasma jet is also investigated. to that end, longitudinal geometric configuration for the electrodes was chosen because it would increase the jet length. electrical characteristics, jet length dependencies on the applied voltage and gas flow rate wer...

The content of amino acids in plasma and urine from male albino rabbits was determined by ion-exchange chromatography and compared to values for other species. In general, the amino acids present, in the plasma and urine of rabbits are those commonly found in other species. In contrast to human urine in which t,he cont,ent of hi&dine is usually greater than the two methylated derivatives, the c...

The profile of organic acids in plasma of patients with a deficiency of medium-chain acyl-CoA dehydrogenase (EC 1.3.99.3) was determined by gas-liquid chromatography of trimethylsilylated derivatives of the acids isolated by ethyl acetate extraction. All 13 patients had increased concentrations of free octanoate, cis-4-decenoate, and decanoate in their plasma. Cis-4-decenoate, an intermediary m...

metronidazole and it’s derivatives are drugs that have both antiprotozoal and anti bacterial effect.the reproductive toxicity of metronidazole has been shown in some studies. to investigate the effect of metronidazole on spermatogenesis in adult male rats, this study was designed. eighteen wistar male rats (70-90days old) were randomly divided into three groups. animals in group i (control grou...

CONTEXT Rectal administration of artemisinin derivatives is a potentially lifesaving emergency treatment of severe malaria. Many different preparations are marketed in tropical countries, but their pharmacokinetic disposition and clinical efficacy may vary. OBJECTIVE To review the pharmacokinetics, efficacy, and safety of rectally administered artesunate, artemisinin, dihydroartemisinin, and ...

BACKGROUND Rigorous studies are necessary to demonstrate suitability of metabolomics platforms to profile metabolites in archived plasma within epidemiologic studies of human disease, for which attenuation of effect estimates due to measurement error is a key concern. METHODS Using a liquid chromatography-tandem mass spectrometry platform, we quantified 257 metabolites from archived plasma to...