BACKGROUND AND AIMS Despite the recent enormous increase in the number of studies on polyploid species, no studies to date have explored the population dynamics of these taxa. It is thus not known whether the commonly reported differences in single life-history traits between taxa of different ploidy levels result in differences in population dynamics. METHODS This study explores differences ...

Increased ploidy is common in tumors but treatments for tumors with excess chromosome sets are not available. Here, we characterize high-ploidy breast cancers and identify potential anticancer compounds selective for the high-ploidy state. Among 354 human breast cancers, 10% have mean chromosome copy number exceeding 3, and this is most common in triple-negative and HER2-positive types. Women w...

During polyploidization the megakaryocyte (MK) undergoes endomitosis, which involves skipping late anaphase and cytokinesis.1,2 As a regulator of anaphase and cytokinesis, our laboratory implicated survivin in this process due to the absence of survivin protein in endomitotic mouse MKs,3 which are typically of high ploidy. Gurbuxani et al4 also noted survivin’s down-regulation at the mRNA level...

ABSTRACT- Bromus danthoniae Trin. is an annual grass species which grows mainly on dry grassy rocky mountain slopes and grassy steppe, and is grazed by many herbivores and recognized as a useful pasture plant. The chromosome number, morphological and anatomical traits of 82 genotypes of B. danthoniae belonging to three sub-taxa were investigated. Twenty-seven quantitative and 20 qualitative mor...

To investigate the patterns of DNA ploidy and proliferating activity in breast cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation were examined for DNA content, ploidy and S-phase fraction. DNA assay was done using a CAS interactive image analyzing system. All of the cas...

BACKGROUND The optimal approach to diagnosis and treatment of localized prostate cancer remains controversial. Deoxyribonucleic acid (DNA) ploidy has been suggested as an important predictor for outcome in prostate cancer. The purpose of this study was to correlate DNA ploidy with disease-specific survival in patients with clinically localized prostate cancer treated with no intent to cure. M...