نتایج جستجو برای: pml

تعداد نتایج: 3358  

2017
Zhi-Ling Shan Xin-Yu Zhu Peng-Peng Ma Hui Wang Jianbin Chen Jun Li Liang Zhong Bei-Zhong Liu

Promyelocyte leukemia‑retinoic acid receptor α (PML‑RARα) is known as a fusion gene of acute promyelocytic leukemia (APL). Previous studies have reported that neutrophil elastase (NE) cleaves PML‑RARα in early myeloid cells, which leads to the removal of the nuclear localization signal (NLS) in PML and increases the incidence of APL. The resultant PML without the NLS is termed PML(NLS‑). The ai...

Journal: :Blood 2010
Elizabeth E Gardiner Michael C Berndt

phagic vesicles after treatment with these agents. Functionally, activation of autophagy by the mammalian target of rapamycin (mTOR) inhibitor triggers PML/RARA destabilization in the NB4 APL cell line, resulting in enhanced ATRA-induced differentiation. Conversely, the autophagy inhibitor BafA impedes treatment-induced PML/ RARA degradation and biologic response. These results are important in...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Wen-Xiao Xu Sheng-Zhi Liu Di Wu Guo-Fen Qiao Jinglong Yan

BACKGROUND/AIMS Promyelocytic leukemia (PML) protein is a tumor suppressor that fuses with retinoic acid receptor-α (PML-RARα) to contribute to the initiation of acute promyelocytic leukemia (APL). Arsenic trioxide (ATO) upregulates expression of TGF-β1, promoting collagen synthesis in osteoblasts, and ATO binds directly to PML to induce oligomerization, sumoylation, and ubiquitination. However...

Journal: :Journal of cell science 2009
Asne Jul-Larsen Amra Grudic Rolf Bjerkvig Stig Ove Bøe

Nucleoporins and the promyelocytic leukemia protein (PML) represent structural entities of nuclear pore complexes and PML nuclear bodies, respectively. In addition, these proteins might function in a common biological mechanism, because at least two different nucleoporins, Nup98 and Nup214, as well as PML, can become aberrantly expressed as oncogenic fusion proteins in acute myeloid leukemia (A...

1965
Laura Adang Joseph Berger

Before embarking on experimental therapies for progressive multifocal leukoencephalopathy (PML), the diagnosis needs to be unequivocally established. Improving the underlying immunodeficiency state is the best initial approach to the management of PML. Immunosuppressive therapies should be discontinued when feasible. In the patient with AIDS, highly active antiretroviral therapy should be admin...

Journal: :The Journal of biological chemistry 2012
Sona Hubackova Katerina Krejcikova Jiri Bartek Zdenek Hodny

Tumor suppressor PML is induced under viral and genotoxic stresses by interferons and JAK-STAT signaling. However, the mechanism responsible for its cell type-specific regulation under non-stimulated conditions is poorly understood. To analyze the variation of PML expression, we utilized three human cell types, BJ fibroblasts and HeLa and U2OS cell lines, each with a distinct PML expression pat...

Journal: :Journal of virology 2012
Nirojini Sivachandran Xueqi Wang Lori Frappier

EBNA1 is the only nuclear Epstein-Barr virus (EBV) protein expressed in both latent and lytic modes of infection. While EBNA1 is known to play several important roles in latent infection, the reason for its continued expression in lytic infection is unknown. Here we identified two roles for EBNA1 in the reactivation of latent EBV to the lytic cycle in epithelial cells. First, EBNA1 depletion in...

Journal: :Cancer research 1996
H Yoshida K Kitamura K Tanaka S Omura T Miyazaki T Hachiya R Ohno T Naoe

Acute promyelocytic leukemia (APL) is associated with a chromosomal translocation t(15;17) and successfully differentiated by all-trans-retinoic acid (ATRA) in vivo as well as in vitro. The PML-retinoic acid receptor alpha (RARA) oncoprotein, which is generated by the translocation, blocks the differentiation, and ATRA is thought to modulate the dominant negative function of PML-RARA. However, ...

Journal: :Molecular and cellular biology 2005
Andrew A Lane Timothy J Ley

Expression of the PML-retinoic acid receptor alpha (PML-RARalpha) fusion protein is the initiating genetic event for acute promyelocytic leukemia (APL), but the molecular mechanisms responsible for disease initiation are not yet clear. Several observations have suggested that early myeloid cells are uniquely susceptible to transformation by PML-RARalpha. Recently, we have shown that the early m...

Journal: :IEEE Transactions on Antennas and Propagation 2021

Wrapping a computation domain with perfectly matched layer (PML) is one of the most effective methods imitating/approximating radiation boundary condition in Maxwell and wave equation solvers. Many PML implementations often use smoothly-increasing attenuation coefficient to increase absorption for given thickness, and, at same time, reduce numerical reflection from interface between PML. In dis...

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