The Large Area Telescope (LAT) on board the Gamma-ray Large-Area Space Telescope (GLAST) is a pair-conversion gamma-ray detector designed to explore the gamma-ray universe in the 20 MeV– 300 GeV energy band. The Tracker subsystem of the LAT will perform tracking of electron and positrons to determine the origin of the gamma-ray. The design and performance of the GLAST LAT Tracker are described ...

Cluster of differentiation 59 (CD59) is a glycosylphosphatidylinositol-anchored protein. Cross-linking of CD59 with specific monoclonal antibodies can cause a series of intracellular signal transduction events. However, the underlying molecular mechanisms are poorly understood. Linker for activation of T-cells (LAT) is a crucial adaptor protein in T-cell signaling, and its phosphorylation and p...

The radio properties of blazars detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope have been observed contemporaneously by the Very Long Baseline Array (VLBA). In total, 232 sources were observed with the VLBA. Ninety sources that were previously observed as part of the VLBA Imaging and Polarimetry Survey (VIPS) have been included in the sample, as well as 1...

In this paper, we present a novel Kalman filter approach to combine a hydrodynamic model-derived lowest astronomical tide (LAT) surface with tide gauge record-derived LAT values. In the approach, tidal water levels are assimilated into the model. As such, the combination is guided by the model physics. When validating the obtained “Kalman-filtered LAT realization” at all tide gauges, we obtaine...

In this paper, we present a novel Kalman filter approach to combine a hydrodynamic model-derived lowest astronomical tide (LAT) surface with tide gauge record-derived LAT values. In the approach, tidal water levels are assimilated into the model. As such, the combination is guided by the model physics. When validating the obtained “Kalman-filtered LAT realization” at all tide gauges, we obtaine...

In this paper, we present a novel Kalman filter approach to combine a hydrodynamic model-derived lowest astronomical tide (LAT) surface with tide gauge record-derived LAT values. In the approach, tidal water levels are assimilated into the model. As such, the combination is guided by the model physics. When validating the obtained “Kalman-filtered LAT realization” at all tide gauges, we obtaine...

During herpes simplex virus type 1 (HSV-1) latent infection in human dorsal root ganglia, limited viral transcription, which has been linked to HSV-1 reactivation ability, takes place. To study the involvement of this transcription in HSV-1 replication in neuronal cells and consequently in viral latency, we constructed stably transfected neuronal cell lines containing (i) the entire HSV-1 laten...

PURPOSE To determine effects of the marine macrolides swinholide A (Swin A) and jasplakinolide (Jas), alone or in conjunction with latrunculin B (Lat B) on outflow facility in monkeys. METHODS Total outflow facility was measured by two-level constant-pressure perfusion of the anterior chamber before and after exchange with Swin A, Jas, or vehicles followed by continuous anterior chamber infus...

To determine the mechanism of latrunculin B (LAT-B)-induced decrease in outflow resistance and the effect of LAT-B on the cornea, structural changes of the trabecular meshwork (TM) and the corneal endothelium following LAT-B were studied in the live monkey eye. LAT-B (0.5 microM) and vehicle were administered by anterior chamber exchange and infusion with cationized and non-cationized gold solu...

Dorsal root ganglion neurons, which express herpes simplex virus (HSV) latency-associated transcript (LAT) during experimental latent infection, were investigated by in situ hybridization. The number of LAT-positive neurons was determined by examination of ganglion serial sections. In other latently infected mice, the number of ganglion neurons that reactivated HSV antigen after explant culture...