A 67-year-old man was referred to our hospital in March 2000 for evaluation of poikiloderma on the entire body surface. The lesions started as an itching rash on the buttock in 1965 and had gradually spread, especially during summer months. Erosions and/or ulcers had formed on the trunk and limbs a few times per year since 1968. These lesions healed within a month without treatment, leaving eit...

A 65-year-old male presented with chronic mechanical back pain and a 6-month history of a discrete, hyperpig-mented reticular rash on his lower back. On further questioning, the patient admitted to daily use of an electric heating pad over the distribution of the rash (Figure 1). The diagnosis was erythema ab igne (EAI). Historically, EAI has been associated with repeated and prolonged exposure...

Hajdu-Cheney syndrome is an autosomal dominant acroosteolysis syndrome, in which clinical and radiological abnormalities develop at different stages of life. A 26-year-old woman visited our rheumatology clinic for progressive shortening of her terminal phalanges. Radiographs showed acro-osteolysis and classic midphalangeal band-like resorption of the terminal phalanges affecting multiple digits...

To the Editor: A 54‐year‐old man developed painful ulcers on the neck one month ago, followed by periorbital edema. The ulcers then spread to his trunk, back, and upper arms. He had muscle weakness, mild muscle soreness with activity, and dysphagia for foods for the past three weeks. He was diagnosed as drug eruption in a local hospital and received irregular corticosteroids therapy for two wee...

Chronic radiodermatitis is defined as a chronic inflammation of the skin associated with exposure to ionizing radiation. It usually presents in individuals who, because of their profession, have been repeatedly exposed to low doses of radiation over a long period of time without appropriate protection. Several treatments have been described, including topical 5-fluorouracil, dermabrasion, ablat...

1. Kindler T. congenital poikiloderma with traumatic bulla formation and progressive cutaneous atrophy. Br J Dermatol 1954; 66: 104-11. 2. Yazdanfar A, Hashemi B. Kindler syndrome: report of three cases in a family and a brief review. Int J Dermatol 2009; 48:145-52. 3. Penagos H, Jaen M, Sancho MT, Saborio MR, Fallas VG, Siegel DH, et al. Kindler syndrome in Native Americans from Panama: report...

on his lower back and upper extremities. Each eruption was a bean-sized solitary papule ( fig. 1 a). Many of the papules had erosions or crusts due to excoriation. Some papules were arranged linearly or clustered to form small plaques. Steroid ointment was ineffective. He also had other cutaneous manifestations of dermatomyositis such as heliotrope rash, flagellate erythema of the upper back, p...

I read with great interest the recent article by Sinha et al.1 Interestingly, one rare condition that often mimics dyskeratosis congenita, and that needs to be distinguished from it, is Kindler Syndrome (KS). KS primarily occurs secondary to "loss of function" mutations in the FERMT1 gene. Mode of inheritance is autosomal recessive. Interestingly, FERMT1 gene mutations are absent in 30% of case...

Loss of Kindlin 1 (Kin1) results in the skin blistering disorder Kindler Syndrome (KS), whose symptoms also include skin atrophy and reduced keratinocyte proliferation. Kin1 binds to integrins to modulate their activation and more recently it has been shown to regulate mitotic spindles and cell survival in a Plk1-dependent manner. Here we report that short-term Kin1 deletion in mouse skin resul...