Introduction. Periprosthetic infections are a major problem in orthopedic surgery. The most optimal way to influence the bacterial film is suppress early stages of its formation. use hydrogel coatings for prevention periprosthetic an effective measure, while process coating implant can be simplified due situ systems. Aim. purpose research develop and study antibacterial preoperative treatment i...

Ritonavir is crystalline solid which very slightly soluble in water yet having high dose. This condition necessitates enhancement of solubility before developing into dosage forms. Melt-quenching recently exploring technique for amorphous dispersions (ASDs) drugs to with a hydrophilic carrier enhance solubility. ASDs have drawback poor thermodynamic stability needs be considered. The current wo...

Adsorption of therapeutic proteins to material surfaces can be a pivotal issue in drug development, especially for low concentration products. Surfactants are used limit adsorption losses. For each formulation component, surface is the result combination its diffusion and rates. The latter difficult measure accurately because depletion layer forms rapidly bulk solution above bare surface, slowi...