Piperazinyl-amide derivatives of N-alpha-(3-trifluoromethyl-benzenesulfonyl)-L-arginine (1) were synthesized as graftable thrombin inhibitors. The possible disturbance of biological activity due to a variable spacer-arm fixed on the N-4 piperazinyl position was evaluated in vitro, against human alpha-thrombin, and in blood coagulation assay. Molecular modelling (in silico analysis) and X-ray di...

In order to expand the properties and applications of aliphatic absorbable polyesters, a new biodegradable block copolymer family, poly(ester amide)-b-poly(ε-caprolactone) (PEA-b-PCL), was synthesized and characterized. These copolymers were synthesized by first preparing l-phenylalanine-based poly(ester amide) macroinitiators (Phe-PEAs) with free amine end groups via a solution polycondensatio...

The present work aims at investigating the thermal properties of a wide range of semicrystalline nanocomposites based on poly(amide)-6 (PA6), ethylene-vinyl acetate copolymer (EVA), poly(ε-caprolactone) (PCL) or polypropylene (iPP), in combination with various types of nanofillers (layered silicates, carbon nanotubes, sepiolite, or POSS). We report on the effect of nanofillers on the quasi-isot...

Objective(s): The main aim of current research was to develop a novel magnetically responsive hydrogel by radical polymerization of carboxymethyl cellulose (CMC) on acryl amide (Am) using N,N'-methylene bis acrylamide  (MBA)  as a crosslinking agent, potassium persulfate (KPS) as a free radical initiator, and  magnetic montmorillonite ( mMT)  nanoclay as nano-...

Carboxylated pyrrole (Pyr, a index)- and carbazole (Cbz, b index)-containing monomers 6-7a/b and 9a/b have been readily synthesized from the monobenzyl ester of L-glutamic acid and triamine 2 using Clauson-Kaas and amide coupling reactions. In contrast to Pyr-containing compounds 6-7a, and 9a, the three Cbz-containing monomers 6-7b, and 9b have been found electroactive and were successfully ele...

Sweden regulates new psychoactive substances, including fentanyl analogs, individually. This reactive scheduling procedure enabled the existence of a recreational market for unscheduled analogs sold from surface webshops. We measure interest in 24 named and impact scheduling. scraped posts threads on Swedish internet forum Flashback.org, 2012–2019. The sample consists with total 8761 posts. con...

We examine if cell adhesion to the surface of an intraocular lens varies with the period of implantation. Samples of extracted intraocular lenses (IOLs) that had been implanted during 1987-2000 (n=72, early group) and those during 2001–2014 (n=182, late group) were included. IOLs were stained with hematoxylin and eosin and grouped according to the presence or absence of cellular deposits on the...

The synthesis of polyimides (PIs) containing polydimethylsiloxane (PDMS) with controlled chain length and the formation higher-order structures were studied. Polycondensation was carried out using diphenyl-3,3',4,4'-tetracarboxylic dianhydride (BPDA) diamine oligomers having amino groups on both ends PDMS. obtained poly(amic acid) (PAA) PI showed good solubility in several common polar solvents...

Composite materials were prepared with granular corn starch (CS) or potato starch (PS) and poly(ester amide) resin (PEA), with starch volume fractions (f) up to 0.40. Tensile yield properties were evaluated at strain rates of 0.0017–0.05 s. Yield stress of the CS-PEA materials increased with strain rate and starch content. The strain rate effect became more pronounced as the starch content incr...