7-Ethyl-10-hydroxycamptothecin (SN-38) loaded poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Pluronic F-108) and poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) nanoparticles were successfully prepared by a modified film hydration method and characterized by scanning electric microscopy (SEM), transmission electron microscopy (TEM), atomic force mic...

BACKGROUND Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. METHODS Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore their drug-release behavior. The drug-l...

AIM To determine the prevalence of poly-pharmacy and pattern associated drug- drug interactions among CKD patients. OBJECTIVE assess various classes drugs prescribed – interactions. comorbidities METHOD A descriptive prospective study 6 months duration that was carried out to review medical case records adult patients attending GGH tertiary care hospital. CONCLUSION The polypharmacy is predomin...

This article reviews the use of multifunctional polymers founded on high-molecular weight poly(ethylene glycol) (PEG). The design of new PEG derivatives assembled in a dendrimer-like multimeric fashion or bearing different functionalities on the same molecule is described. Their use as new drug delivery systems based on the conjugation of multiple copies or diversely active drugs on the same bi...

A targeted micellar drug delivery system is developed from a biocompatible and biodegradable amphiphilic polyester, poly(Lac-OCA)-b-(poly(Tyr(alkynyl)-OCA)-g-mannose) (PLA-b-(PTA-g-mannose), that is synthesized via controlled ring-opening polymerization of O-carboxyanhydride (OCA) and highly efficient "Click" chemistry. Doxorubicin (DOX), a model lipophilic anticancer drug, can be effectively e...

We have previously reported furan-maleimide Diels-Alder chemistry as a new methodology to couple maleimide-modified antibodies on furan-functionalized polymeric carriers in the preparation of immuno-nanoparticles for targeted drug delivery. In this report, we focus on the characterization, self-assembly behavior and drug encapsulation of two types of furan-functionalized co-polymers: poly(2-met...

Abstract: This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer the copolymer/stabilizer Pluronic® F127. The mean diameter cylindrical rod shape nanoformulation particles 248±2.4-260±3.2 nm an acceptable po...

A class of new biodegradable hydrogels based on poly(ethylene glycol) methacrylate-graft-poly(glutamic acid) and poly(ethylene glycol) dimethacrylate was synthesized by photoinduced polymerization. Because all the polymeric constituents were highly hydrophilic, crosslinking could be performed in aqueous solutions. This type of crosslinked hydrogel was prepared by modifying a select number of ac...

Partially purified preparations of mouse interferon, administered during the 2-day period following the administration of a toxic dose of 5-fluorouracil (FUra), yielded significant protection from mortality in BALB/c x DBA/2 F1 mice. Protection against FUra-induced toxicity was also observed when the interferon inducer polyinosinic-polycytidylic acid (poly I.poly C) was administered with FUra. ...