نتایج جستجو برای: polya pcr
تعداد نتایج: 175977 فیلتر نتایج به سال:
The evaluation of the performance of a continuous diagnostic measure is a commonly encountered task in medical research.We develop Bayesian non-parametric models that use Dirichlet process mixtures and mixtures of Polya trees for the analysis of continuous serologic data.The modelling approach differs from traditional approaches to the analysis of receiver operating characteristic curve data in...
While most siRNAs induce sequence-specific target mRNA cleavage and degradation in a process mediated by Ago2/RNA-induced silencing complex (RISC), certain siRNAs have also been demonstrated to direct target RNA reduction through deadenylation and subsequent degradation of target transcripts in a process which involves Ago1/RISC and P-bodies. In the current study, we present data suggesting tha...
POLR3G is expressed at high levels in human pluripotent stem cells (hPSCs) and is required for maintenance of stem cell state through mechanisms not known in detail. To explore how POLR3G regulates stem cell state, we carried out deep-sequencing analysis of polyA+ and smallRNA transcriptomes present in hPSCs and regulated in POLR3G-dependent manner. Our data reveal that POLR3G regulates a speci...
Giant viruses from the Mimiviridae family replicate entirely in their host cytoplasm where their genes are transcribed by a viral transcription apparatus. mRNA polyadenylation uniquely occurs at hairpin-forming palindromic sequences terminating viral transcripts. Here we show that a conserved gene cluster both encode the enzyme responsible for the hairpin cleavage and the viral polyA polymerase...
Single-electron avalanche distributions in gaseous multipliers affect their efficient detection and that of single UV-photons. In this work, we investigated the shape single-photo-electron spectra single- double-stage Resistive Plate WELL (RPWELL) detector configurations, operated $\mathrm{Ne/CH_{4}}$ $\mathrm{Ar/CH_{4}}$. Discharge-free operation was reached over a broad dynamic range, with ch...
microRNAs (miRNAs) are a large class of endogenous short RNAs that repress gene expression. Many miRNAs are conserved throughout evolution, and dysregulation of miRNA pathways has been correlated with an increasing number of human diseases. In animals, miRNAs typically bind to the 3' untranslated region (3'UTR) of target mRNAs with imperfect sequence complementarity and repress translation. Des...
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