Poly(ether-block-amide) (PEBA, commercialized as Pebax) copolymer membranes show a highly promising platform for preparing high-performance CO2 capture from process streams containing CH4 and N2. Pebax combines high affinity with the desired mechanical strength polymeric thanks to its flexible polyether segment hard polyamide block, respectively. Furthermore, researchers have been improving per...

Disclosed is an inhibitor of the expression of CTGF gene, which comprises a pyrrole-imidazole polyamide. The pyrrole-imidazole polyamide has an N-methylpyrrole unit (hereinafter, referred to as “Py”), an N-methylimidazole unit (hereinafter, referred to as “Im”) and a ϝ-aminobutanoic acid unit. In the pyrrole-imidazole polyamide, the region of the ϝ-aminobutanoic acid unit is folded to form an U...

In an effort to quantitate Py-Im polyamide concentrations in vivo, we synthesized the C-14 radioactively labeled compounds 1-3, and investigated their tumor localization in a subcutaneous xenograft model of prostate cancer (LNCaP). Tumor concentrations were compared with representative host tissues, and exhibited a certain degree of preferential localization to the xenograft. Compound accumulat...

The functional silica/polyamide-imide composite films were prepared via simple ultrasonic blending, after the silica nanoparticles were modified by cationic surfactant-cetyltrimethyl ammonium bromide (CTAB). The composite films were characterized by scanning electron microscope (SEM), thermo gravimetric analysis (TGA) and thermomechanical analysis (TMA). CTAB-modified silica nanoparticles were ...

The design of molecules that damage a selected DNA sequence provides a formidable opportunity for basic and applied biology. For example, such molecules offer new prospects for controlled manipulation of the genome. The conjugation of DNA-code reading molecules such as polyamides to reagents that induce DNA damages provides an approach to reach this goal. In this work, we showed that a bipyridi...

A naturally derived monomer, allylated gallic acid (AG), was herein proposed as a monomer for interfacially polymerized thin-film composite nanofiltration membranes. We investigated the synthesis of polyester membranes by varying concentration AG and reaction time with trimesoyl chloride. In addition, we demonstrated polyesteramide film using mixture m-phenylene diamine, although there are few ...

Interfacial polymerization of polyamide was conducted using hydrophobic and hydrophilic membrane support. The effects monomer concentration were investigated, the resulting thin-film composite membranes tested for their performance in dye removal different flow configurations. results showed that a dense layer successfully formed on support, while with very loose structure became smoother more ...

Aberrant overexpression of ERG induced by the TMPRSS2-ERG gene fusion is likely involved in the development of prostate cancer. Synthetic pyrrole-imidazole (PI) polyamides recognize and attach to the minor groove of DNA with high affinity and specificity. In the present study, we designed a PI polyamide targeting TMPRSS2-ERG translocation breakpoints and assessed its effect on human prostate ca...

In this study, acicular nano-hydroxyapatite (n-HA) was used to make a new biomimetic composite with polyamide (poly hexamethylene adipamide) by a unique technique. The physical and chemical characteristics of the composites were tested. It was found that these synthesized n-HA crystals were similar to bone apatite in size, phase composition and crystal structure. The biomimetic n-HA crystals we...