The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and thereby to maintain the desired drug concentrations during treatment. This idealized objective can be achieved by targeting the drugs to a specific organ or tissue with the help of controlling the release rate of the drug during the transit time in ...

The purpose of this research was to formulate and systematically evaluate in vitro performances of chitosan microspheres containing Mitomycin-C. Chitosan microspheres containing Mitomycin-C were prepared by simple emulsification phase separation technique using glutaraldehyde as a cross-linking agent. Results of preliminary trials indicate that volume of cross-linking agent, time for cross-link...

The purpose of research work was to develop and optimize mucoadhesive microspheres of glibenclamide incorporated in in-situ gel for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy. Chitosan (mucoadhesive) based microspheres of glibenclamide were prepared by emulsificationcrosslinking method. Glutaraldehyde was used as crosslinking agent. A 32 factorial...

The purpose of the present study was to design muco-adhesive chitosan microspheres containing amoxicillin. Chitosan microspheres with a small particle size and good sphericity were prepared by a spray-drying method followed by chemical treatment with a chemical crosslinking agent (glutaraldehyde). Parameters affecting the crosslinking extent of the crosslinking time and the concentration of the...

BACKGROUND In this study, we produced poly(ethylene glycol) (PEG) microspheres of different sizes and adsorbing a medicinal plant mixture, and verified their effect in vitro on the viability, superoxide production, and bactericidal activity of phagocytes in the blood. METHODS The medicinal plant mixture was adsorbed onto PEG microspheres and its effects were evaluated by flow cytometry and fl...

The objective of this work was to formulate and evaluate a controlled-release Oxypentifylline microspheres that fulfill the requirements for extended release medications using Ammonio Methacrylate Copolymer RS100 as polymeric material. The microsphere were prepared by quasiemulsion solvent diffusion technique. The effect of process variables such as drug to polymer ratio, stirring rate, and con...

The aim of this study was to prepare and evaluate poly(ε-caprolactone) (PCL) microspheres containing acetazolamide. Microspheres were prepared by solvent evaporation method. The influence of formulation factors (polymer: drug ratio, aqueous: oil phase ratio, concentration of aqueous phase, stirring speed and stirring time) on morphology, particle size, encapsulation and recovery efficiency were...

Microspheres are one of the novel drug delivery system and are formulated conveniently to obtain prolonged or controlled drug delivery to enhance the bioavailability and target drug to the specific sites. Ritonavir loaded ethylcellulose buoyant microspheres were formulated using ethylcellulose as rate retarding material. Buoyant microspheres were formulated by emulsion solvent diffusion method....

An overview of microspheres manufactured for use in biomedical applications based on recent literature is presented in this review. Different types of glasses (i.e. silicate, borate, and phosphates), ceramics and polymer-based microspheres (both natural and synthetic) in the form of porous , non-porous and hollow structures that are either already in use or are currently being investigated with...

Optical Doppler tomography is demonstrated to be a simple, accurate, and noncontact method for measuring the fluid velocity of laminar flow in small-diameter (~0.5-mm) ducts. Studies are described that utilize circular (square) plastic (glass) ducts infused with a moving suspension of polymer microspheres in air and buried in an optically turbid medium. The measurement of Doppler-shifted freque...