Polymeric materials bearing polar groups constitute a class of macromolecules with interest in number uses. Because the direct synthesis employing polymerization strategies from monomers is very often precluded by catalyst poisoning or uncontrolled side reactions, alternative postpolymerization route consisting modifying previously prepared polymer continuously progressing. However, such poster...

Bioorthogonal catalysis using transition-metal-based complexes (TMCs) is a promising approach for converting substrates to desired products in complex cellular media. Notably, the situ activation of prodrugs or synthesis active drugs with aim complement existing treatments diseases such as cancer has received significant attention. Whereas focus initially been on optimizing ligands enhance acti...

Hybrid copolymers, which contain segments with distinct structures and properties, are useful materials in various applications such as novel plastics, polymeric catalysis, smart materials, self-assembly, and bionanotechnology. They can be prepared through conjugation of hybrid polymeric segments or polymerization with corresponding initiators. The latter approach is particularly attractive as ...

The cross-linked microbeads with average diameter of 106-300 μm, [poly(EGDMA-MATrp)], were obtained by copolymerization reaction N-methacryloyl-L-(+)-tryptophan methyl ester (MATrp) ethylene glycol dimethacrylate (EGDMA) and successfully applied as a heterogeneous catalyst in conjugate addition nitromethane to substituted 2-iminochromenes aqueous media. A variety 2-amino-4-(nitromethyl)-4H-chro...

the accurate prediction of protein stability is one of the most challenging goals in protein formulation and delivery. in this study, a gradient rp-hplc method is described for the separation of human growth hormone (hgh) variants as deamidated and oxidized forms. the methodology employed a polymeric poly (styrene-co-divinylbenzene) column and a 1ml/min flow rate of a linear gradient of 0.1% v/...