A triplex-forming oligopyrimidine has been attached at its 5'-end to a photoreactive psoralen derivative and used to target a sequence which forms part of the coding region of the human aromatase gene. The 20 base pair sequence is not a perfect triplex target since it contains three pyrimidine interruptions within the purine-rich strand. Despite this, we have detected triplex-directed photoaddu...

In this paper, we have systematically investigated the aggregation behavior, confined crystallization and controlled growth of a novel polyolefin analogue-containing block copolymers (BCPs), i.e., polymethylene-b-poly(acrylic acid) diblock copolymers (PM-b-PAA). On cooling from a homogenous DMF solution at 80 °C, PM-b-PAA was found to crystallize and aggregate with well-defined disk-like micell...

To investigate polymer friction and the role of surface roughness on polymer tribology, microtribometry testing was performed using hydrocarbon films ranging in roughness from a molecularly smooth monolayer to extremely rough polymethylene coatings that were prepared on both the substrate (a flat silicon wafer) and the probe (a 6 mm borosilicate lens). The results show that the rough topography...

We have engineered a new class of pH-responsive polymer films on gold surfaces by first developing a controlled, surface-catalyzed polymerization to prepare a copolymer film consistent with poly(methylene-co-ethyl acetate) and subsequently hydrolyzing the ester side chains to varying extents to yield carboxylic acids (denoted as PM-CO2H). When pH is increased, the acid groups become deprotonate...

Because of their high cost, lysolecithins are generally not considered useful detergents for the purification of membrane-bound enzymes. Therefore, we have synthesized a structural analog of lysolecithin with similar physical properties for which synthesis is straightforward. This analog is 1-palmitoylpropanediol-3-phosphocholine. To compare the efficacy of the two detergents for the purificati...

ÐN-Benzoyloxy-2-thiopyridone (12) was shown to induce single-strand nicks in duplex DNA upon irradiation with visible light (l&350 nm). This ®nding led to the design of a series of compounds, in which an acridinyl nucleus was covalently linked to the N-benzoyloxy-2-thiopyridone unit. These conjugates (15, 16, 17 and 18) were synthesized and evaluated as novel DNA photocleaving reagents. Optimal...

We investigate whether and how the environmental consciousness (greenness for short) of firms banks is reflected in pricing bank credit. Using a large international sample syndicated loans over period 2011–2019, we find that green indeed reward being form cheaper loans—however, only after ratification Paris Agreement 2015. Such are also more likely term loans, with fewer covenants reflect firms...