Objective: NRG1 is one of the genes that was reported to have susceptibility alleles effecting phenotype schizophrenia. There are many SNPs (single nucleotide polymorphisms) located in gene with suspected which were associated In this study, we investigated potential associations between schizophrenia and polymorphisms rs4560751 rs3802160. Material Methods: We collected DNA samples 96 patients ...

The advances made on genetic influence response and side effects of psychiatric pharmacotherapy improved the concept personalized psychiatry. current evidence suggests that testing can be useful in patients who did not respond or tolerate at least one previous pharmacotherapy. Approximately 90% all drugs are metabolized by only few different cytochrome enzymes. Pharmacogenetic research has prov...

Nav1.5-derived Na+ current (INa) exerts a pivotal role in the depolarization phase of cardiomyocytes’ action potential, and, therefore, changes INa can contribute to fatal arrhythmias. Nav1.5 displays naturally occurring ethnicity-related polymorphisms, which might alter functioning and pharmacology channel. Some studies have shown how sing...

molecular genetics selection on individual genes is a promising method to genetically improve economically important traits in livestock. the insulin like growth factor-i (igf-i) gene may play important roles in growth of multiple tissues, including muscle cells, cartilage and bone. the objectives of the present study were the estimate the haplotype frequencies of the igf-i gene polymorphisms i...

several asthma susceptibility loci, including a region containing the vitamin d receptor (vdr) gene located at chromosome 12q, have been identified using genome-wide screens. our aim is to investigate the association between single nucleotide polymorphisms (snps) in vdr gene and asthma. one hundred one asthma patients and 206 healthy controls were enrolled in this study. genotypes were determin...

background: endometriosis influenced by both genetic and environmental factors. associations of glutathione s-transferases (gsts) genes polymorphisms in endometriosis have been investigated by various researchers; however, the results are not consistent.objective: we examined the associations of gstm1 and gstt1 null genotypes and gstp1 313 a/g polymorphisms with endometriosis in an iranian popu...

Vascular Endothelial Growth Factor (VEGF) plays an important role in tumor angiogenesis. Although several studies revealed on association of VEGF polymorphisms with gastric cancer, still the results are inconclusive.

Olanzapine is an atypical antipsychotic widely used for the treatment of schizophrenia, which often causes serious adverse drug reactions. Currently, there are no clinical guidelines implementing pharmacogenetic information on olanzapine. Moreover, Dutch Pharmacogenomics Working Group (DPWG) states that CYP2D6 phenotype not related to olanzapine response or side effects. Thus, objective this ca...

objective(s): asthma results from the interaction between genetic and environmental factors. adam33 gene on chromosome 20p13 is associated with asthma and airway hyperresponsiveness. materials and methods: this is a case-control study, where four snps s1 (rs3918396), t1 (rs2280091), t2 (rs2280090), v4 (rs2787094) of adam33 gene have been assessed in patients with allergic asthma and normal cont...

conclusions these results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of hbv infection and susceptibility to hbv infection. results persistent hbv infection was associated with il-10-1082 ag (p = 0.001) and gg (p = 0.004) genotypes and g (p = 0.000) allele. il-10-819 t/c and -592 a/c genotype and allele frequencies did not show any correlation with the ...