Topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. The new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. The adhesive capacity of hydroxypropyl methylcellulose (HPMC) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

We examined the phase behavior of various polyoxyethylene sorbitan fatty acid ester (polysorbates)/ethanol/isopropyl myristate (IPM)/150 mM NaCl solution (NaClaq) systems in order to prepare a microemulsion containing a low ratio of ethanol, which is more suitable for in vivo application. Using polyoxyethylene sorbitan trioleate (Tween 85), which has a large lipophilic moiety, as a surfactant c...

The Span 40 (sorbitan monooleate)/Tween (polyoxyethylene sorbitan monolaurate) system gives faceted vesicles with angular surfaces, rather than spherical vesicles. Herein, a continuous and facile preparation method, based on the subcritical water-assisted emulsification solvent diffusion, was presented to yield two major minor axes (Type A) closer polyhedron B). Type A, B, were likely be formed...

Abstract In this report, the conductivity mechanism of Ca 2+ ‐ion in polyoxyethylene (POE) solid polymer electrolytes (SPEs) for calcium secondary batteries is investigated by broadband electrical spectroscopy studies. SPEs are obtained dissolving into POE hosting matrix three different salts: CaTf 2 , Ca(TFSI) and CaI . The investigation electric response synthetized reveals presence materials...