Prion diseases are a group of fatal neurodegenerative disorders associated with structural conversion of a normal, mostly alpha-helical cellular prion protein, PrP(C), into a pathogenic beta-sheet-rich conformation, PrP(Sc). The structure of PrP(C) is well studied, whereas the insolubility of PrP(Sc) makes the characterization of its structure problematic. No proteins similar to PrP, except for...

Graduate Institute of Biochemical and University, No. 259, Wenhua 1st Rd., Gu Republic of China. E-mail: [email protected] Neurosurgery Department, Chang Gung Taiwan, Republic of China Department of Plastic and Reconstructive S Tao-yuan 333, Taiwan, Republic of China Division of Hematology/Oncology, Departm Memorial Hospital at Linkou, Tao-yuan Cit Department of Chemical Engineering, Ming City, Tai...

Three substituted zinc (II) phthalocyanines (one anionic, one cationic and one hydrophobic) have been compared to two clinically used photosensitisers, 5,10,15,20-tetra (m-hydroxyphenyl) chlorin (mTHPC) and polyhaematoporphyrin (PHP), as potential agents for photodynamic therapy (PDT). Oxygen-consumption experiments, performed to follow the photo-oxidation of tryptophan, histidine and bovine se...

The aim of the work is to develop composition transdermal therapeutic system anti-inflammatory action based on active pharmaceutical ingredients natural origin. Materials and methods. Selection adhesive materials, plasticizers solvents, effect introduction base ingredients, determination optimal temperature drying time, pharmacological screening was performed by physicochemical, biopharmaceutic...

The cause of the conformational change of normal cellular prion protein (PrP) into its disease-associated form is unknown. Posttranslational modifications, such as glycosylation, acetylation, S-nitrosylation, and phosphorylation, are known to induce protein conformational changes. Here, we investigated whether phosphorylation could induce the conformational change of PrP because PrP contains se...

Polyphenols content and antioxidant activity are directly related to the quality of wine. Wine also contains sulfites, which are added during the winemaking process. The present study aimed to evaluate the effects of sulfites on the assays commonly used to measure the antioxidant activity and polyphenols and flavonoids content of white wines. The effects of sulfites were explored both in the st...

New polyoxadiazole-based supported ionic liquid membranes were designed and elaborated for the first time to be used as a middle- high-temperature polymer electrolyte membrane fuel cell application. The proposed molecular design combined hydroxyl-functionalized sulfonated polyoxadiazole, hydrophilic polyvinylpyrrolidone specific protic liquid, thus allowing elaboration of with remarkable physic...

In this study, synthesis of copper nanoparticles and effect of the reaction conditions on the particle size were investigated. The copper nanoparticles were synthesized and stabilized in a narrow temperature range in the presence of polyvinylpyrrolidone under nitrogen atmosphere. Reaction temperature and concentration ratio of the reducing agent to the precursor (R/P) as two main conditions i...

Numerous studies have indicated that a modified proteinase K-resistant form of an endogenous brain protein, prion protein (PrP), is associated with scrapie infection in animals. This scrapie-associated PrP modification appears to occur posttranslationally in brain, but its molecular nature is not known. To learn about the normal PrP biosynthesis and whether it is altered by scrapie infection in...