Parkinson plus diseases, comprising mainly progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are rare neurodegenerative conditions. We designed a double-blind randomized placebo-controlled trial of riluzole as a potential disease-modifying agent in Parkinson plus disorders (NNIPPS: Neuroprotection and Natural History in Parkinson Plus Syndromes). We analysed the accuracy of...

To determine whether brain atrophy differs between the two subtypes of progressive supranuclear palsy (PSP), Richardson's syndrome (PSP-RS), and PSP parkinsonism (PSP-P), and whether such atrophy directly relates to clinical deficits and the severity of tau deposition. We compared 24 pathologically confirmed PSP cases (17 PSP-RS and 7 PSP-P) with 22 controls from a Sydney brain donor program. V...

Fifty years ago, Richardson, Steele and Olszewski presented at the American Neurological Association meeting the clinical and neuropathological features of eight patients, representing the first description of progressive supranuclear palsy (PSP). Their classical paper, remarkably accurate, insightful and complete, still forms the basis for recognizing this disease [1,2]. The post-mortem examin...

OBJECTIVES This study sought to assess the diagnostic accuracy of cone beam computed tomography (CBCT) with different voxel sizes and intraoral digital radiography with photostimulable phosphor (PSP) plate for detection of periapical (PA) bone lesions. MATERIALS AND METHODS In this ex vivo diagnostic study, one-millimeter defects were created in the alveolar sockets of 15 bone blocks, each wi...

There is limited information on the cross-neutralisation of neurotoxic venoms with antivenoms. Cross-neutralisation of the in vitro neurotoxicity of four Asian and four Australian snake venoms, four post-synaptic neurotoxins (α-bungarotoxin, α-elapitoxin-Nk2a, α-elapitoxin-Ppr1 and α-scutoxin; 100 nM) and one pre-synaptic neurotoxin (taipoxin; 100 nM) was studied with five antivenoms: Thai cobr...

In a broad region in parameter space (K, τ ) the slave system can anticipate the master system: y(t) = x(t+ τ) [1, 2]. A recent series of papers have extended these results to a setup in which the dynamical system is nonautonomous (e.g. fed by noise) and f models an excitable neuron (FitzHugh-Nagumo or Hodgkin-Huxley model) [3, 4]. The fact that anticipated synchronization is verified also in t...

Pathological skin picking (PSP) is a rather frequent but yet underrecognized impulse control disorder at the crossroads of dermatology, psychology, and psychiatry. The present pilot study assessed the feasibility and efficacy of self-help interventions in the disorder. Habit reversal training (HRT), the current treatment-of-choice intervention, was tested against a newly developed technique ent...

Alzheimer disease (AD) is characterized by numerous senile plaques (SP) in addition to widespread neocortical neurofibrillary tangles (NFT). Some elderly have pathologic aging (PA), which is characterized by numerous SP composed of diffuse amyloid deposits with few or no NFT confined to the limbic lobe. Both AD and PA represent a range of Alzheimer type pathology (ATP). Some cases of progressiv...