Introduction. One of the most progressive directions modern stage development biology is deepening knowledge about mechanisms regulation metabolic processes, in particular signal molecules that transmit information to cell through ion channels and nuclear receptors associated with G-protein or enzymatic activity. The Farnesoid X receptor (FXR) mainly expressed liver intestines, it regulates key...

The aim of this study was to evaluate the influence of gender differences on triglyceride (TG) response after a fatty meal in clinically defined heterozygous (h) patients with familial hypercholesterolemia (FH). Nineteen hFH men were age-matched with an equal number of premenopausal women. Plasma TG was measured before and 2, 4, 6, and 8 hr after a standardized fat load. The men with hFH had a ...

PURPOSE This study aimed to examine the effect of 30 and 60 min of moderate-intensity treadmill walking on postprandial triacylglycerol concentrations ([TAG]) in healthy girls. METHODS Eighteen 10- to 14-yr-old girls (mean ± SD; body mass = 48 ± 11 kg, body fat = 19.0 ± 4.6%, peak oxygen uptake [V˙O2] = 47 ± 6 mL·kg·min) completed three 2-d trials in a counterbalanced crossover design, each s...

BACKGROUND A high fructose intake can lead to postprandial hypertriacylglycerolemia. The underlying mechanism is unclear. OBJECTIVE The objective of the study was to investigate the mechanisms involved in fructose-induced hypertriacylglycerolemia and the contribution of de novo lipogenesis in an acute setting. DESIGN In a randomized, crossover study, 14 subjects were given a fructose or glu...

The effect of gemfibrozil on postprandial lipoprotein metabolism was investigated in a 12-week, randomized, double-blind, placebo-controlled trial in 20 non-insulin-dependent diabetic patients with moderate hypertriglyceridemia. The patients were given a meal containing 78 g of fat and 345,000 units of vitamin A to label chylomicrons and their remnants. Plasma obtained at various times during t...

Despite clinical evidence that postprandial lipemia and chylomicrons could contribute to atherosclerosis, direct evidence is lacking. The study by Weinstein et al(1) provides evidence to suggest that intact chylomicrons might be atherogenic by using genetically altered mice lacking Gpihbp1 protein, which may play a major role in the lipolysis of triglyceride-rich lipoproteins. However, the stud...

BACKGROUND The process of randomization is used commercially to harden fats as an alternative to partial hydrogenation, but its effects on cardiovascular disease risk factors are uncertain. OBJECTIVE The objective was to compare the chronic and acute effects of randomization of a fat rich in 1,3-distearyl, 2-oleyl glycerol on fasting and postprandial lipids, glucose, insulin, and activated cl...

BACKGROUND Exaggerated postprandial lipemia (PPL) is a factor in atherogenesis, involving endothelial dysfunction and enhanced oxidative stress. We examined the effect of ciprofibrate therapy on these parameters in type 2 diabetes mellitus. METHODS AND RESULTS Twenty patients entered a 3-month, double-blind, placebo-controlled study. Each subject was studied fasting and after a fatty meal, at...