The first one-pot selective synthesis of unsymmetric tertiary amines is reported by the amination of two types of alcohols with primary amines via the development of a simple CuAlOx-HT catalyst and enables the synthesis of unsymmetric amines in a wide variety of primary amines and alcohols.

A straightforward synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O16 has been achieved following a sequential glycosylation strategy. A minimum number of steps was used for the synthesis of the target compound involving a one-pot glycosylation and a protecting group manipulation. All intermediate reactions afford their products in high yield, and the glycos...

We report a flexible de novo synthesis of phenolic dihydroxanthene fluorophores. The synthesis relies on a one-pot formation of an aldehyde intermediate which can be diversified in 60-70% overall yield, providing an efficient access to this family of near-infrared emitting fluorophores.

An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedländer's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study.

In this work, the efficiency, generality and applicability of new Bronsted acidic ionic liquid (BAIL) 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride {[Msei]Cl} as heterogeneous and green catalyst for organic transformations are studied. Herein, the following one-pot multi-component reactions in the presence of [Msei]Cl are investigated: (i) the synthesis of quinoxaline derivatives fr...

A zeolitic platinum-encapsulated microcapsule was successfully employed in the one-pot tandem synthesis of hydrazone directly from cyclohexanol with high conversion, selectivity and reusability due to the promising protection of the zeolitic shell around the catalyst.

A combinatorial ionic-liquid-supported "catch-and-release" strategy for oligosaccharide synthesis (combi-ICROS) is reported. A series of β-(1→6) glucan di-, tri- and tetra-saccharides were synthesized in one pot to showcase the versatility of the strategy.

Multi-responsive amphiphilic gold nanoparticles (AuNPs) protected by graft poly(ether amine) have been prepared simply by a one-pot photochemical synthesis in the presence of thio-graft poly(ether amine) (gPEA-SH) and the mechanism was studied in detail.

A novel one-pot method for the synthesis of chemiluminescence functionalized AgNPs has been reported and an ECL sensor has been developed for the detection of M. tuberculosis DNA.

A novel one-pot synthesis of the 2-substituted 3-carboxy-4-quinolone/chromone derivatives from readily available 3-oxo-3-arylpropanoates and amides/acyl chlorides is reported, without any transition metal aid.