Prothrombin (FII) is activated to α-thrombin (IIa) by prothrombinase. Prothrombinase is composed of a catalytic subunit, factor Xa (fXa), and a regulatory subunit, factor Va (fVa), assembled on a membrane surface in the presence of divalent metal ions. We constructed, expressed, and purified several mutated recombinant FII (rFII) molecules within the previously determined fVa-dependent binding ...

In connection with those paragraphs of my paper Applications of the theory of Boolean rings to general topology (Trans. Amer. Math. Soc. vol. 41 (1937) pp. 375-481) dealing with regular spaces, I have long been curious to know whether certain results proved there could be used to obtain the well known theorem that a separable (Hausdorff) space is metrizable if (and only if) it is regular. Since...

Kaposi's sarcoma-associated herpesvirus (KSHV) contains several open reading frames (ORFs) encoding proteins capable of initiating signal transduction pathways. Among them is the K15 ORF, which consists of eight exons encoding a protein with 12 predicted transmembrane domains and a cytoplasmic C terminus. When transiently expressed, the 8-exon K15 transcript gives rise to a protein with an appa...

In this article, the effects of different foam production times and temperatures on the mechanical, physical, and structural properties of polypropylene (PP) foam has been investigated. The microcellular PP foams were carried out using supercritical carbon dioxide (sc-CO2) as a physical foaming agent in a batch process. The samples were placed in a pressure vessel and were saturated ...