Routine in vitro screening of a new synthetic series of 3,5-substituted 2-methylisoxazolidines revealed that three imidazole analogs (PR 967-248, PR 967-234, and PR 969-566) and, to a lesser extent, a triazole analog (PR 988-399) exerted rather potent antifungal activity against three systemic and four dermatophytic classes of fungi. When tested in vivo for ability to eradicate Candida vaginiti...

The performance of the adaptive projection receiver (PR), a recently proposed joint detector for CDMA with error control coding, is investigated. It is shown that the adaptive version of the PR performs better than the algebraic PR. A close approximation of the error probability for the adaptive PR is derived. The performance improvement of the adaptive PR, which is of the order of 1-2dB in Eb=...

BACKGROUND To assess the prognostic value of progesterone receptor (PR) expression in patients with hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer subgroups. METHODS A retrospective review of breast cancer patients who underwent mastectomy or breast-conserving surgery between January 1998 and December 2007 was performed. The prognostic imp...

The ovarian steroid hormones estradiol (E) and progesterone (P) play important roles in reproductive physiology and behavior. The effects of E and P are mediated by their respective receptors, estrogen receptor (ER) and progestin receptor (PR) which function as transcription factors. PR is expressed as two isoforms, full length PR-B and the N-terminally truncated PR-A, by the induction of E in ...

Estrogens act in brain to profoundly influence neurogenesis, sexual differentiation, neuroprotection, cognition, energy homeostasis, and female reproductive behavior and physiology through a variety of mechanisms, including the induction of progestin receptors (PRs). PRs are expressed as two isoforms, PR-A and PR-B, that have distinct functions in physiology and behavior. Because these PR isofo...

Human progesterone receptor (PR) contains a motif that interacts with the SH3 domain of Src and mediates rapid activation of Src and downstream MAPK (Erk-1/-2) without relying on the transcriptional activity of the receptor. Here we investigated the role and intracellular location of this nontranscriptional activity of PR. Progestin activation of Src/MAPK occurred outside the nucleus with the B...

PR-104, currently in clinical trial, is converted systemically to the dinitrobenzamide nitrogen mustard prodrug PR-104A, which is reduced selectively in hypoxic cells to cytotoxic hydroxylamine (PR-104H) and amine (PR-104M) metabolites. Here, we evaluate the roles of this reductive metabolism, and DNA interstrand cross-links (ICL), in the hypoxic and aerobic cytotoxicity of PR-104. Using a pane...

We report results from high Prandtl number turbulent thermal convection experiments. The viscous boundary layer and the Reynolds number are measured in four different fluids over wide ranges of the Prandtl number Pr and the Rayleigh number Ra, all in a single convection cell of unity aspect ratio. We find that the normalized viscous layer thickness may be represented as delta(v)/L=0.65Pr(0.24)R...

1 Progesterone receptors (PR) are critical mediators of mammary gland development and 2 contribute to breast cancer progression. Progestin-induced rapid activation of 3 cytoplasmic protein kinases leads to selective regulation of growth-promoting genes by 4 phospho-PR species. Herein, we show that phosphorylation of PR Ser81 is ck25 dependent and progestin-regulated in intact cells, but also oc...